A case series and literature review of infections due to Myroides spp.: identification of contributing factors and emerging antibiotic susceptibility trends
This article has been Reviewed by the following groups
Discuss this preprint
Start a discussion What are Sciety discussions?Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
Introduction. Infections forby Myroides spp. can lead to significant morbidity and mortality, particularly in immunocompromised patients with underlying co-morbidities. Recent reports have highlighted its intrinsic and acquired drug resistance, making it a particularly challenging infectious agent to combat.
Methods. Myroides spp. isolated and reported in clinically significant urine samples were considered for the study. Identification of the organism was done via the VITEK 2C system. Antibiotic susceptibility testing was done using both manual and automated methods following Clinical and Laboratory Standards Institute (CLSI) guidelines. Existing literature was searched on MEDLINE using PubMed.
Results. We present a series of five catheter-associated urinary tract infections due to Myroides odoratimimus , with sensitivity to only minocycline. This is the first case from Western India, and the third case in the existing literature that shows Myroides sensitivity only to minocycline. Our literature review is the first to systematically describe contributory factors to infection, allowing us to devise a clinically relevant tool that delineates contributory factors and efficacious drugs in Myroides spp . infection.
Conclusion. Myroides spp . infections, previously considered rare and opportunistic, need cognizance and diagnostic suspicion especially in particular associated conditions.
Article activity feed
-
-
The work presented is clear and the arguments well formed. This study would be a valuable contribution to the existing literature. This is a study that would be of interest to the field and community. Thank you for your submission, all reviewers are satisfied with the manuscript (which reports a clear set of cases of Myroides spp. infections and subsequent literature review) will be a valueable contribution to the field. Congratualtions and we welcome future submissions to Access Microbiology.
-
Comments to Author
1. Description of the case(s) Authors report 5 Myroides spp. infections in hospitalised patients, with evidence of extensive antibiotic resistance. Due to the number of presentations and the drug resistance, authors carried out a literature review of MEDLINE to assess trends in risk factors and drug resistance. While containing some self identified limitations (i.e. restricted only to MEDLINE) the review highlights key risk factors (Indwelling catheters/devices - Prolonged hospitalization - Invasive/surgical procedures - Diabetes - CKD) and Target therapeutics options (Chloramphenicol - Levofloxacin - Cotrimoxazole - Meropenem - Minocycline). Also some findings including evidence that there are cases of removal of in-dwelling medical devices, associated with infections, allow for self recovery in …
Comments to Author
1. Description of the case(s) Authors report 5 Myroides spp. infections in hospitalised patients, with evidence of extensive antibiotic resistance. Due to the number of presentations and the drug resistance, authors carried out a literature review of MEDLINE to assess trends in risk factors and drug resistance. While containing some self identified limitations (i.e. restricted only to MEDLINE) the review highlights key risk factors (Indwelling catheters/devices - Prolonged hospitalization - Invasive/surgical procedures - Diabetes - CKD) and Target therapeutics options (Chloramphenicol - Levofloxacin - Cotrimoxazole - Meropenem - Minocycline). Also some findings including evidence that there are cases of removal of in-dwelling medical devices, associated with infections, allow for self recovery in patient infections which could be investigated further. 2. Presentation of results The cases are presented succinctly with key factors clearly indicating pathology. 3. How the style and organization of the paper communicates and represents key findings Following the case study information, the authors then report the literature findings and discuss these sufficiently. 4. Literature analysis or discussion Following the case study information, the authors then report the literature findings and discuss these sufficiently. 5. Any other relevant comments The manuscript will be a valuable tool in raising awareness and as a reference for similar case in the future. Minor typography issues: Line 72 (M. Phaeus change to M. phaeus).
Please rate the quality of the presentation and structure of the manuscript
Good
To what extent are the conclusions supported by the data?
Strongly support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
Yes
-
Comments to Author
The authors report five case studies of patients infected with Mycoides species that were multiply drug resistant. The only antibiotic tested to which all five infections were sensitive was minocycline. As this is a rare observation, the authors summarize in table 1 results of an extensive literature search of papers describing Mycoides infections. The data are discussed and presented in a simpler format in table 3. The authors confirm that appropriate ethical procedures were followed. The quality of the English is good, but the word "paper" on line 80 should please be deleted. Use of the verb "was done" twice in line 38 and again in lone 91 is rather ugly, but with this extremely minor editing, the paper is acceptable without change.
Please rate the quality of the presentation and …
Comments to Author
The authors report five case studies of patients infected with Mycoides species that were multiply drug resistant. The only antibiotic tested to which all five infections were sensitive was minocycline. As this is a rare observation, the authors summarize in table 1 results of an extensive literature search of papers describing Mycoides infections. The data are discussed and presented in a simpler format in table 3. The authors confirm that appropriate ethical procedures were followed. The quality of the English is good, but the word "paper" on line 80 should please be deleted. Use of the verb "was done" twice in line 38 and again in lone 91 is rather ugly, but with this extremely minor editing, the paper is acceptable without change.
Please rate the quality of the presentation and structure of the manuscript
Good
To what extent are the conclusions supported by the data?
Strongly support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
Yes
-