A case of atypical vivax malaria with a global review of reports on myriads of morpho-variations in parasitized red blood cells
This article has been Reviewed by the following groups
Discuss this preprint
Start a discussion What are Sciety discussions?Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
Plasmodium vivax , one of the major species associated with human malaria, continues to be a major public health problem in many parts of the world. Numerous studies related to vivax malaria have described quantitative haematological findings (level of haemoglobin, thrombocytopaenia, haematocrit values), but diverse morphological changes of parasite forms within infected red blood cells (iRBCs) have been mentioned only in few studies. Here we report a case of a 13-year-old boy who presented with fever, significant low platelet counts and hypovolaemia that created a diagnostic dilemma. Detection of microgametocytes by microscopic examinations, further confirmed by multiplex nested PCR assays and response to anti-malarials, helped to make the diagnosis. We present an atypical case of vivax malaria with a review of morpho-variations of iRBCs and have summarized the characteristics that aid in creating increased awareness among laboratory health professionals and public health workers.
Article activity feed
-
-
The work presented is clear and the arguments well formed. This study would be a valuable contribution to the existing literature.
-
-
-
Comments to Author
This paper is presenting a case of vivax malaria infection with a challenge for the diagnosis. The vivax specie, predominant in the Asia region with a particular infection cycle can cause diagnosis issue particularly in severe case as it is unexpected. Red blood cells morphological variations are common future of plasmodium infection with a variety of presentation which is well presented in this article. Overall, the paper is quit well written but the English need to be reviewed before it can be published. Below are some comments/suggestions that need to be taking into account to improve the article Line 36: reduce the space after "among". Please consider this remark for the entire paper and correct as it is recurrent. Lines 65-66: please review the word "co-infection" and write I consistently Lines …
Comments to Author
This paper is presenting a case of vivax malaria infection with a challenge for the diagnosis. The vivax specie, predominant in the Asia region with a particular infection cycle can cause diagnosis issue particularly in severe case as it is unexpected. Red blood cells morphological variations are common future of plasmodium infection with a variety of presentation which is well presented in this article. Overall, the paper is quit well written but the English need to be reviewed before it can be published. Below are some comments/suggestions that need to be taking into account to improve the article Line 36: reduce the space after "among". Please consider this remark for the entire paper and correct as it is recurrent. Lines 65-66: please review the word "co-infection" and write I consistently Lines 74-75: please add year of publication to be consistent with the previous citations Line 91-92: please re-write the sentence to make it clearer to link to the topic or otherwise delete it as the current status doesn't link it to the topic Lines 102-105: same observation as above. The sentences need to be clarified or deleted Results: Line 110: you stated low blood pressure with measure of 110/40 mmHg. However, according to the patient age, the only low measure is the diastolic value. Please review Lines 111-125: please be consistent with the unit used for the platelet count measurement Line 133-134: the value of the "cardiac ejection fraction 55%" need to be more elaborated since there is no previous measurement to compare. You only put the value with no comment/interpretation. What is the usefulness for in your case For all the hematology parameters values: please add in bracket, the normal ranges to help for the interpretation What was the rational for the antibiotic treatment. In the same line, was there any antibiotic prescribed at discharge? Discussion section: Your discussion is more general. I will suggest to add more details or elaborate on previous studies showing features of hematology parameters (clinical information) in vivax malaria as you did. Figure 1: I will suggest to add an arrow to guide your comment showing the microgametocyte
Please rate the quality of the presentation and structure of the manuscript
Good
To what extent are the conclusions supported by the data?
Strongly support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
Yes
-
This study would be a valuable contribution to the existing literature. This is a study that would be of interest to the field and community. The reviewers have highlighted minor concerns with the work presented. Please ensure that you address their comments.
-
Comments to Author
Line 41: Write the full name of the species at the first appearance in the text Plasmodium vivax Lines 50, 52,58,68: It is better to write P. vivax malaria Line 50: It is better to write "has shown" instead of "have shown Line 62: Reduce the extra space in "ex- flagellation" Line 86: Write the number 8 in full Lines 89, 100: It is better to write P. falciparum malaria Line 101: It is better to write "have been reported" instead of "has been reported Line 104: It is "showed a distribution" instead of "showed a in a distribution Line 103: Correct the unit of measurement, it is "mg/dL" instead of "mg/dl
Please rate the quality of the presentation and structure of the manuscript
Good
To what extent are the conclusions supported by the data?
Strongly support
…
Comments to Author
Line 41: Write the full name of the species at the first appearance in the text Plasmodium vivax Lines 50, 52,58,68: It is better to write P. vivax malaria Line 50: It is better to write "has shown" instead of "have shown Line 62: Reduce the extra space in "ex- flagellation" Line 86: Write the number 8 in full Lines 89, 100: It is better to write P. falciparum malaria Line 101: It is better to write "have been reported" instead of "has been reported Line 104: It is "showed a distribution" instead of "showed a in a distribution Line 103: Correct the unit of measurement, it is "mg/dL" instead of "mg/dl
Please rate the quality of the presentation and structure of the manuscript
Good
To what extent are the conclusions supported by the data?
Strongly support
Do you have any concerns of possible image manipulation, plagiarism or any other unethical practices?
No
Is there a potential financial or other conflict of interest between yourself and the author(s)?
No
If this manuscript involves human and/or animal work, have the subjects been treated in an ethical manner and the authors complied with the appropriate guidelines?
Yes