Rapid Inactivation of SARS-CoV-2 with Ozonated Water
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SciScore for 10.1101/2020.11.01.361766: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources After adding Na2S2O3, the virus solutions were serially diluted in 10-fold steps using serum-free minimum essential medium (MEM) and then inoculated onto Vero cell monolayers in a 12-well plate. Verosuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are …
SciScore for 10.1101/2020.11.01.361766: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources After adding Na2S2O3, the virus solutions were serially diluted in 10-fold steps using serum-free minimum essential medium (MEM) and then inoculated onto Vero cell monolayers in a 12-well plate. Verosuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
Despite the significant inactivating effect of ozone water, the present study may have some limitations. First, ozone concentrations measured in this study may not reflect the exact value of ozone water in the microtube contacting the virus, since it is known that the ozone concentration decreases rapidly in the environment. Given that this study focused only on SARS-CoV-2, the inactivating effect of ozone water on other microorganisms needs to be investigated in future studies. Furthermore, since the results of this experiment were obtained in a static state (not dynamic) rather than in running water, different outcomes may be observed when these two conditions are compared. In future studies, more practical information can be obtained by evaluating the ozone water concentration and exposure time for the optimal inactivating effect under various conditions. Currently, we are faced with the need to prevent SARS-CoV-2 infection for a long time, and a new lifestyle, so called “with corona”, is needed worldwide. Washing hands is a critical way to prevent fomite infection, as suggested by the WHO. Very recently, the virucidal efficacy of formulated microbicidals, such as ethyl alcohol, para-chloro-meta-xylenol, and quaternary ammonium compounds, has been reported for inactivating SARS-CoV-2 [25]. On the other hand, it has been pointed out that SARS-CoV-2 may survive for 9 hours on the skin [9]. In addition, most of the touchable surfaces in a designated hospital for COVID19 were ...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
About SciScore
SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.
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SciScore for 10.1101/2020.11.01.361766: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources After adding Na2S2O3, the virus solutions were serially diluted in 10-fold steps using serum-free minimum essential medium (MEM) and then inoculated onto Vero cell monolayers in a 12-well plate. Verosuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following …SciScore for 10.1101/2020.11.01.361766: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources After adding Na2S2O3, the virus solutions were serially diluted in 10-fold steps using serum-free minimum essential medium (MEM) and then inoculated onto Vero cell monolayers in a 12-well plate. Verosuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Despite the significant inactivating effect of ozone water, the present study may have some limitations. First, ozone concentrations measured in this study may not reflect the exact value of ozone water in the microtube contacting the virus, since it is known that the ozone concentration decreases rapidly in the environment. Given that this study focused only on SARS-CoV-2, the inactivating effect of ozone water on other microorganisms needs to be investigated in future studies. Furthermore, since the results of this experiment were obtained in a static state (not dynamic) rather than in running water, different outcomes may be observed when these two conditions are compared. In future studies, more practical information can be obtained by evaluating the ozone water concentration and exposure time for the optimal inactivating effect under various conditions. Currently, we are faced with the need to prevent SARS-CoV-2 infection for a long time, and a new lifestyle, so called “with corona”, is needed worldwide. Washing hands is a critical way to prevent fomite infection, as suggested by the WHO. Very recently, the virucidal efficacy of formulated microbicidals, such as ethyl alcohol, para-chloro-meta-xylenol, and quaternary ammonium compounds, has been reported for inactivating SARS-CoV-2 [25]. On the other hand, it has been pointed out that SARS-CoV-2 may survive for 9 hours on the skin [9]. In addition, most of the touchable surfaces in a designated hospital for COVID-19 were...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- No funding statement was detected.
- No protocol registration statement was detected.
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