Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection

  1. Victoria Hall
  2. Sarah Foulkes
  3. Ferdinando Insalata
  4. Peter Kirwan
  5. Ayoub Saei
  6. Ana Atti
  7. Edgar Wellington
  8. Jameel Khawam
  9. Katie Munro
  10. Michelle Cole
  11. Caio Tranquillini
  12. Andrew Taylor-Kerr
  13. Nipunadi Hettiarachchi
  14. Davina Calbraith
  15. Noshin Sajedi
  16. Iain Milligan
  17. Yrene Themistocleous
  18. Diane Corrigan
  19. Lisa Cromey
  20. Lesley Price
  21. Sally Stewart
  22. Elen de Lacy
  23. Chris Norman
  24. Ezra Linley
  25. Ashley D. Otter
  26. Amanda Semper
  27. Jacqueline Hewson
  28. Silvia D’Arcangelo
  29. Meera Chand
  30. Colin S. Brown
  31. Tim Brooks
  32. Jasmin Islam
  33. Andre Charlett
  34. Susan Hopkins

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Abstract

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  1. Version published to 10.1056/nejmoa2118691
  2. ScreenIT

    SciScore for 10.1101/2021.11.29.21267006: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: This study was registered, number ISRCTN11041050, and received approval from the Berkshire Research Ethics Committee on 22 May 2020.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    5 We used STATA software (version 15.1; StataCorp LLC, College Station, TX, USA) for all analyses.
    STATA
    suggested: (Stata, RRID:SCR_012763)
    StataCorp
    suggested: (Stata, RRID:SCR_012763)

    Results from OddPub: Thank you for sharing your code and data.

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    The most important limitation of our study is the relatively small number of participants continuing to contribute follow-up time to key vaccination exposures: unvaccinated, ChAdOx1 and BNT162b2 short interval. This particularly affects the precision of estimates and our ability to assess potential waning following two-doses of ChAdOx1, and >15 months after primary infection in unvaccinated participants. We consider that the strengths of our study design and speed of vaccine deployment significantly limit the impact of depletion-of-susceptible bias (which particularly affects studies on vaccine-waning),19 however we recognise some residual confounding may remain.

    Results from TrialIdentifier: We found the following clinical trial numbers in your paper:

    IdentifierStatusTitle
    ISRCTN11041050NANA

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.11.29.21267006v1 on medRxiv