Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur
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Abstract
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SciScore for 10.1101/2020.04.09.033233: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication Authentication: Vero E6 cells were from ATCC with authentication.
Contamination: We confirm that all cells were tested as mycoplasma negative.Table 2: Resources
Experimental Models: Cell Lines Sentences Resources Vero E6 cells were from ATCC with authentication. Vero E6suggested: RRID:CVCL_XD71)Software and Algorithms Sentences Resources The structure was determined by molecular replacement (MR) with the PHASER22 and Phenix 1.17.123 using the SARS-CoV-2 Mpro (PDB ID: 6LU7) as a search template. Phenixsuggested: (Phenix, …SciScore for 10.1101/2020.04.09.033233: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication Authentication: Vero E6 cells were from ATCC with authentication.
Contamination: We confirm that all cells were tested as mycoplasma negative.Table 2: Resources
Experimental Models: Cell Lines Sentences Resources Vero E6 cells were from ATCC with authentication. Vero E6suggested: RRID:CVCL_XD71)Software and Algorithms Sentences Resources The structure was determined by molecular replacement (MR) with the PHASER22 and Phenix 1.17.123 using the SARS-CoV-2 Mpro (PDB ID: 6LU7) as a search template. Phenixsuggested: (Phenix, RRID:SCR_014224)The model from MR was subsequently subjected to iterative cycles of manual model adjustment with Coot 0.824 and refinement was completed with Phenix REFINE25. Cootsuggested: (Coot, RRID:SCR_014222)Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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