Hybrid immunity versus vaccine-induced immunity against SARS-CoV-2 in patients with autoimmune rheumatic diseases

  1. Padmanabha Shenoy
  2. Sakir Ahmed
  3. Aby Paul
  4. Somy Cherian
  5. Rashwith Umesh
  6. Veena Shenoy
  7. Anuroopa Vijayan
  8. Sageer Babu
  9. Nivin S
  10. Arya Thambi

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Abstract

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  1. Version published to 10.1016/s2665-9913(21)00356-8
  2. ScreenIT

    SciScore for 10.1101/2021.08.26.21258418: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsConsent: Serum and plasma samples of these patients have been stored for future research with patients’ informed consent.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    Quantitative measurement of IgG Antibodies to S1 protein of the SARS-CoV-2 virionwas done using the Elecsys Anti-SARS-CoV-2 Chemiluminescent assay (Roche, Switzerland).
    Anti-SARS-CoV-2
    suggested: None
    Software and Algorithms
    SentencesResources
    All analysis and graphical representations were carried out in R version 3.4 using various packages including ggplot2, ggforce, Hmisc, rstatix, and rocr.
    ggplot2
    suggested: (ggplot2, RRID:SCR_014601)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    The major limitation is that we have not looked at T cell immunogenicity. However, it has already been shown that peak neutralizing antibody titres correlates very well with the protection from COVID-19 infection probably independent of T cell responses[23]. Thus, in patients with AIRD who have had COVID-19 before, having a single dose of vaccine provides 10-50 fold higher humoral immunity than two doses of vaccine in infection naïve patients. This concept of hybrid immunity needs to be recognised and utilized in planning vaccination policies.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.08.26.21258418v1 on medRxiv