Daily testing for contacts of individuals with SARS-CoV-2 infection and attendance and SARS-CoV-2 transmission in English secondary schools and colleges: an open-label, cluster-randomised trial
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
No abstract available
Article activity feed
-
-
SciScore for 10.1101/2021.07.23.21260992: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: A representative of the institution provided consent electronically. Sex as a biological variable not detected. Randomization Randomisation: Schools were randomly assigned 1:1 to either a policy of offering contacts daily testing over 7 days to allow continued school attendance (intervention arm) or to follow usual policy of isolation of contacts for 10 days (control arm). Blinding During the trial, the trial management team were blinded to the combined data. Power Analysis Based on these assumptions we estimated that 58 participating schools in each arm provides 80% power (two-sided alpha=0.05) to detect a difference in attendance between the study arms. Table 2: Resources
… SciScore for 10.1101/2021.07.23.21260992: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: A representative of the institution provided consent electronically. Sex as a biological variable not detected. Randomization Randomisation: Schools were randomly assigned 1:1 to either a policy of offering contacts daily testing over 7 days to allow continued school attendance (intervention arm) or to follow usual policy of isolation of contacts for 10 days (control arm). Blinding During the trial, the trial management team were blinded to the combined data. Power Analysis Based on these assumptions we estimated that 58 participating schools in each arm provides 80% power (two-sided alpha=0.05) to detect a difference in attendance between the study arms. Table 2: Resources
Software and Algorithms Sentences Resources SARS-CoV-2 PCR was performed using the Thermo Fisher TaqPath COVID-19 kit. Thermo Fisher TaqPathsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Additionally, at some stages, schools paused the intervention either because of capacity limitation or because public health officials were concerned about the spread of the Delta lineage or rising transmission in the community. No local public health teams reported concern that transmission was observed to increase because of this study. Previous estimates for the performance of antigen LFDs compared to PCR testing have varied markedly.[6, 22] Here we estimate the overall sensitivity of school-based LFD testing in largely asymptomatic individuals as 53%, which falls within the range of previously reported rates. It is worth noting the findings on transmission in this study are in the context of this level of performance. Specificity was 99.93%. As LFD performance varies by viral load[23] this overall performance is subject to change as the population viral load distribution changes. Consistent with previous reports[6] we find that higher viral loads, i.e. lower PCR cycle threshold values, are associated with increased sensitivity, and therefore LFDs are more likely to detect those who are most infectious.[16] The study has several limitations. Schools and colleges, despite provision of dedicated resources, were not always able to participate due to competing pressures, and it is also likely as a result that data capture was imperfect, e.g. it is possible that not all PCR-positive cases were reported to schools, and not all contacts may have been documented for all index case...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title ISRCTN18100261 NA NA Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
-
