Misinterpretation of viral load in COVID-19 clinical outcomes

Article activity feed

1. Version published to 10.1016/j.virusres.2021.198340

   Apr 1, 2021
2. 

   ScreenIT

   Mar 1, 2021

   SciScore for 10.1101/2020.10.06.20208009: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Institutional Review Board Statement	IACUC: The studies involving human participants were reviewed and approved by the ethical committee of Instituto Estadual do Cérebro Paulo Niemeyer (file number 3.997.619).
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.
   Sex as a biological variable	not detected.
   Cell Line Authentication	not detected.

   Table 2: Resources

   Experimental Models: Cell Lines
   Sentences	Resources
   When comparing different sample types, TA and NPS, we used Ct and ΔCt on paired samples to check whether there was a difference in viral RNA load or in the amount of biological material.	TA suggested: RRID:CVCL_4315)
   Software and Algorithms
   Sentences	Resources
   Statistical analysis: …

   SciScore for 10.1101/2020.10.06.20208009: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Institutional Review Board Statement	IACUC: The studies involving human participants were reviewed and approved by the ethical committee of Instituto Estadual do Cérebro Paulo Niemeyer (file number 3.997.619).
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.
   Sex as a biological variable	not detected.
   Cell Line Authentication	not detected.

   Table 2: Resources

   Experimental Models: Cell Lines
   Sentences	Resources
   When comparing different sample types, TA and NPS, we used Ct and ΔCt on paired samples to check whether there was a difference in viral RNA load or in the amount of biological material.	TA suggested: RRID:CVCL_4315)
   Software and Algorithms
   Sentences	Resources
   Statistical analysis: All data analysis was performed with the GraphPad Prism 6 (GraphPad Software Inc., USA).	GraphPad Prism suggested: (GraphPad Prism, RRID:SCR_002798) GraphPad suggested: (GraphPad Prism, RRID:SCR_002798)

   ---

   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

   ---

   Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

   ---

   Results from TrialIdentifier: No clinical trial numbers were referenced.

   ---

   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

   ---

   Results from JetFighter: We did not find any issues relating to colormaps.

   ---

   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
   • No protocol registration statement was detected.

   ---

   Read the original source
3. 

   Version published to 10.1101/2020.10.06.20208009v1 on medRxiv

   Oct 8, 2020