Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E
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SciScore for 10.1101/2021.07.01.450756: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources Inhibition assay of Human coronavirus 229E: Huh-7 cells were grown in Dulbecco’s Modified Eagle Medium (DMEM) supplemented with 10% fetal bovine serum (10% FBS) and 1% antibiotics. Huh-7suggested: NoneSoftware and Algorithms Sentences Resources (https://www.sigmaaldrich.com/ https://www.sigmaaldrich.com/suggested: (Sigma-Aldrich, RRID:SCR_008988)The 3D structures of compounds (Fig. 2) were obtained from PubChem (https://pubchem.ncbi.nlm.nih.gov/) and then used as … SciScore for 10.1101/2021.07.01.450756: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources Inhibition assay of Human coronavirus 229E: Huh-7 cells were grown in Dulbecco’s Modified Eagle Medium (DMEM) supplemented with 10% fetal bovine serum (10% FBS) and 1% antibiotics. Huh-7suggested: NoneSoftware and Algorithms Sentences Resources (https://www.sigmaaldrich.com/ https://www.sigmaaldrich.com/suggested: (Sigma-Aldrich, RRID:SCR_008988)The 3D structures of compounds (Fig. 2) were obtained from PubChem (https://pubchem.ncbi.nlm.nih.gov/) and then used as ligands. PubChemsuggested: (PubChem, RRID:SCR_004284)https://pubchem.ncbi.nlm.nih.gov/suggested: (PubChem BioAssay, RRID:SCR_010734)The modeling of protein-ligand docking was performed via the publically available AutoDock Vina (http://vina.scripps.edu/) software. http://vina.scripps.edu/suggested: (AutoDock Vina, RRID:SCR_011958)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from JetFighter: Please consider improving the rainbow (“jet”) colormap(s) used on page 44. At least one figure is not accessible to readers with colorblindness and/or is not true to the data, i.e. not perceptually uniform.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- No funding statement was detected.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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