Significance of SARS-CoV-2 specific antibody testing during COVID-19 vaccine allocation
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SciScore for 10.1101/2021.01.28.21250721: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations: The results presented are limited by the restriction of our model and the assumptions made for the parameters explained in the methodology section. We use an extended SIR model which assumes homogenous mixing of the population. We do not stratify the population by age and therefore cannot account for age-dependent model …
SciScore for 10.1101/2021.01.28.21250721: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations: The results presented are limited by the restriction of our model and the assumptions made for the parameters explained in the methodology section. We use an extended SIR model which assumes homogenous mixing of the population. We do not stratify the population by age and therefore cannot account for age-dependent model parameters, such as the infection fatality ratio [13]. The infection transmission rates used in the model are static. In reality, these rates change over time depending on the interventions put in place and community compliance [29, 30]. We assumed that serology tests are 100% sensitive and specific and that vaccines are 100% effective, which do not reflect the real-world circumstances. We did not specify if the serology tests measure IgG or IgM or IgA antibodies. Additionally, we modeled vaccine distribution as a one-dose vaccine. The vaccines available in the market require two-doses separated by 21-28 days [31, 32]. In our model assuming a one-dose vaccine is equivalent to simulating a perfect administration of a two-dose vaccine (e.g., nobody misses the second dose). Although the limitations listed, the model proposed captures the pandemic dynamics and the allocation of vaccines using serology testing. The model provides us with a simple and accurate representation of the benefits of using serology as part of the vaccination process.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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