Wastewater to clinical case (WC) ratio of COVID-19 identifies insufficient clinical testing, onset of new variants of concern and population immunity in urban communities
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
Article activity feed
-
-
SciScore for 10.1101/2022.04.19.22274052: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Field Sample Permit: 2.1 Sample collection, enrichment, concentration, and extraction: Ottawa: 24-hour composite samples of primary clarified sludge were collected from the City of Ottawa’s sole WRRF, the Robert O. Pickard Environmental Centre (ROPEC), starting on Apr. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Ho…
SciScore for 10.1101/2022.04.19.22274052: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Field Sample Permit: 2.1 Sample collection, enrichment, concentration, and extraction: Ottawa: 24-hour composite samples of primary clarified sludge were collected from the City of Ottawa’s sole WRRF, the Robert O. Pickard Environmental Centre (ROPEC), starting on Apr. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:However, RT-PCR nucleic acid clinical tests are not without limitations; first, individuals may decline clinical testing or refuse to seek medical treatment during a pandemic despite being symptomatic, complicating both tracking of cases and contact tracing (Novoa et al., 2021), and second, RT-PCR test results may suffer from a substantial false-negative rate, especially when considering the time of testing in relation to symptom onset and the type of sample collected (sputum, stool, nasopharyngeal, oropharyngeal, etc.) (da Rocha Araujo, 2020; Hatchette, 2009; Wikramaratna et al., 2020). An epidemiologically important event occurred when changes in clinical testing strategies were effected in the province of Ontario (affecting Ottawa, Kitchener, Toronto, Peel and Waterloo), Canada on October 6th, 2020. In response to an increasing backlog of tests, and to ensure individuals could get tested at a specific time with minimal wait (Crawlley et al., 2020), provincial guidelines and the framework for the initiation of SARS-CoV-2 RT-PCR clinical testing were changed from an open-access, walk-in format to one in which individuals were required to book an appointment before testing. This change in testing strategy presented a significant, if brief, barrier for Ontario residents wanting to be tested for COVID-19 by necessitating online bookings, which made it more difficult for groups of the general population to access testing resources. WWS had already been introduced in Ottawa and P...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
-
