Low-density lipoprotein cholesterol levels are associated with poor clinical outcomes in COVID-19
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SciScore for 10.1101/2020.10.06.20207092: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The local ethics committees approved the study protocol.
Consent: Informed consent was waived, given the ambispective and observational nature of the study.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable Exclusion criteria were age < 18 years old, pregnant women, and death in the first 24 h after admission. Table 2: Resources
Software and Algorithms Sentences Resources We performed the statistical analyses with the use of R software, version 3.6.1 (R Project for Statistical Computing) and IBM SPSS Statistics, Version 25.0. R Project for Statisticalsuggested: (R Project for Statistical Computing, RRID:SCR_00190…SciScore for 10.1101/2020.10.06.20207092: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The local ethics committees approved the study protocol.
Consent: Informed consent was waived, given the ambispective and observational nature of the study.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable Exclusion criteria were age < 18 years old, pregnant women, and death in the first 24 h after admission. Table 2: Resources
Software and Algorithms Sentences Resources We performed the statistical analyses with the use of R software, version 3.6.1 (R Project for Statistical Computing) and IBM SPSS Statistics, Version 25.0. R Project for Statisticalsuggested: (R Project for Statistical Computing, RRID:SCR_001905)SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our work presents certain limitations. These observations should be considered hypothesis-generating only due to the intrinsic retrospective nature of the present work. Moreover, the data were subject to selection bias, and the generalizability of the results may be reduced by the fact that we did not evaluate outpatients. We could not measure apoproteins or oxidized forms of main lipoproteins, which may play a detrimental role in the pathogenesis of COVID-19. Finally, for better characterization of this hypolipidemia, our findings should be validated in a large multicentric cohort of COVID-19 patients monitoring the dynamics of lipid profiles before, during the acute phase and follow-up. In conclusion, our results suggest that COVID-19 hypolipidemia is associated with inflammation; In particular, LDL-c could be used as a complementary marker in septic patients for better risk stratification. Upcoming studies should determine to what extent treatment-related resolution of inflammation or changes in lipid levels may impact outcomes; such data are currently lacking.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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