COVID-19 is associated with new symptoms of multiple sclerosis that are prevented by disease modifying therapies
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SciScore for 10.1101/2021.03.08.21253141: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Standard Protocol Approvals, Registrations, and Patient Consents: Ethical approval for UKMSR studies was obtained from South West-Central Bristol Research Ethics Committee (16/SW/0194).
Consent: Participants provided informed consent online.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Statistical Analysis: Data were analysed using IBM SPSS Statistics for Windows, version 26 (IBM Corp., Armonk, N.Y., USA; 2019). SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. …
SciScore for 10.1101/2021.03.08.21253141: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Standard Protocol Approvals, Registrations, and Patient Consents: Ethical approval for UKMSR studies was obtained from South West-Central Bristol Research Ethics Committee (16/SW/0194).
Consent: Participants provided informed consent online.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Statistical Analysis: Data were analysed using IBM SPSS Statistics for Windows, version 26 (IBM Corp., Armonk, N.Y., USA; 2019). SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:In addition, most individuals reported that their new MS symptoms resulted in limitation of their daily activities. We wondered whether people had regarded their COVID-19 symptoms, such as fatigue or cognitive problems that can mimic MS symptoms, as deterioration of their MS. Can we truly distinguish MS deterioration from some systemic symptoms of COVID-19? We cannot answer this question with confidence without paraclinical tests, but we found that most individuals with fatigue, memory, or mobility problems also reported other neurological symptoms suggestive of MS. Although more individuals with anxiety or depression reported an MS exacerbation during their COVID-19 infection than individuals without anxiety or depression, the rate of MS exacerbations was above 50% in both groups, suggesting that over-reporting of symptoms linked to anxiety or depression has not driven these results 17.
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04354519 Recruiting The United Kingdom Multiple Sclerosis Register Covid-19 Subs… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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