The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells

  1. Alan S. Wang
  2. Leo C. Chen
  3. R. Alex Wu
  4. Yvonne Hao
  5. David T. McSwiggen
  6. Alec B. Heckert
  7. Christopher D. Richardson
  8. Benjamin G. Gowen
  9. Katelynn R. Kazane
  10. Jonathan T. Vu
  11. Stacia K. Wyman
  12. Jiyung J. Shin
  13. Xavier Darzacq
  14. Johannes C. Walter
  15. Jacob E. Corn

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Abstract

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  1. Version published to 10.1016/j.molcel.2020.06.014
  2. preLights

    Excerpt

    Cutting to the FACT of the matter – the FACT histone chaperone complex can modify Cas9 behaviour during gene editing, potentially influencing the outcome of different CRISPR approaches

  3. Version published to 10.1101/705657 on bioRxiv