Attack rates amongst household members of outpatients with confirmed COVID-19 in Bergen, Norway: A case-ascertained study

Article activity feed

1. Version published to 10.1016/j.lanepe.2020.100014

   Apr 1, 2021
2. 

   ScreenIT

   Nov 5, 2020

   SciScore for 10.1101/2020.11.02.20224485: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Institutional Review Board Statement	IRB: The study was approved by the Local Ethics Committee (#118664). Consent: All participants and/or their guardians provided written informed consent before inclusion in the study.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.
   Sex as a biological variable	not detected.
   Cell Line Authentication	not detected.

   Table 2: Resources

   Experimental Models: Cell Lines
   Sentences	Resources
   In the microneutralisation (MN) assay, virus infectivity was measured by detecting the amount of nucleoprotein after 24 hours incubation in Vero cells.	Vero suggested: CLS Cat# 605372/p622_VERO, RRID:CVCL_0059)
   Software and Algorithms
   Sentences	Resources
   Graphs were drawn …

   SciScore for 10.1101/2020.11.02.20224485: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Institutional Review Board Statement	IRB: The study was approved by the Local Ethics Committee (#118664). Consent: All participants and/or their guardians provided written informed consent before inclusion in the study.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.
   Sex as a biological variable	not detected.
   Cell Line Authentication	not detected.

   Table 2: Resources

   Experimental Models: Cell Lines
   Sentences	Resources
   In the microneutralisation (MN) assay, virus infectivity was measured by detecting the amount of nucleoprotein after 24 hours incubation in Vero cells.	Vero suggested: CLS Cat# 605372/p622_VERO, RRID:CVCL_0059)
   Software and Algorithms
   Sentences	Resources
   Graphs were drawn in Prism 7 (GraphPad Software, San Diego, CA) Role of the funding sources: The funding bodies had no role in study design, collection, analysis and interpretation of data, in writing the manuscript, and in the decision to submit this paper for publication.	Prism suggested: (PRISM, RRID:SCR_005375) GraphPad suggested: (GraphPad Prism, RRID:SCR_002798)

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   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

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   Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

   The interpretation of our findings has several limitations which may influence our estimation of attack rates. Despite high participation rates, there may have been a bias in who consented to participate, limiting and influencing our interpretation of results. There was also a risk that the index case was not correctly identified, although to minimize this, extensive telephone interviews were conducted once a positive case was identified. Likewise, we cannot exclude the possibility that some cases and household members had a common source of exposure outside the household, although the national shutdown appears to have eliminated the transmission of respiratory viruses in general, as evidenced by the abrupt drop in influenza cases. Lastly, the screening algorithm used by the municipality changed mid-March, with prioritisation of health-care workers and patients with underlying chronic conditions, potentially limiting the identification of patients. In conclusion, we found a higher household attack rate of SARS-CoV-2 than previous studies, and show that serological testing is superior to RT-PCR-testing in assessing attack rates. Children are far more susceptible to household-transmission than previously reported, and relying on RT-PCR for diagnosis may miss the majority of infected children. This highlights the importance of including children when considering measures to reduce spread of SARS-CoV-2 virus. The risk of transmission was highest from index cases with dyspnoea, fe...

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   Results from TrialIdentifier: No clinical trial numbers were referenced.

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   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

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   Results from JetFighter: We did not find any issues relating to colormaps.

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   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
   • No protocol registration statement was detected.

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3. 

   Version published to 10.1101/2020.11.02.20224485v1 on medRxiv

   Nov 4, 2020