A fourth dose of the mRNA-1273 SARS-CoV-2 vaccine improves serum neutralization against the Delta variant in kidney transplant recipients

  1. Ilies Benotmane
  2. Timothée Bruel
  3. Delphine Planas
  4. Samira Fafi-Kremer
  5. Olivier Schwartz
  6. Sophie Caillard

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Abstract

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  1. Version published to 10.1016/j.kint.2022.02.011
  2. ScreenIT

    SciScore for 10.1101/2021.11.25.21266704: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: The study protocol was approved by the local Ethics Committee (comité de protection des personnes de Strasbourg, France, identifier: DC-2013– 1990) and written informed consent was obtained from participants.
    Consent: The study protocol was approved by the local Ethics Committee (comité de protection des personnes de Strasbourg, France, identifier: DC-2013– 1990) and written informed consent was obtained from participants.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    Anti-IgG antibody titers were measured with an ARCHITECT IgG II Quant test (Abbott, Abbott Park, IL, USA; assay range: 1–11360 binding antibody units [BAUs]/mL).
    Anti-IgG
    suggested: None
    Software and Algorithms
    SentencesResources
    Anti-IgG antibody titers were measured with an ARCHITECT IgG II Quant test (Abbott, Abbott Park, IL, USA; assay range: 1–11360 binding antibody units [BAUs]/mL).
    Abbott
    suggested: (Abbott, RRID:SCR_010477)
    All calculations were performed using GraphPad Prism, version 8.0 (GraphPad Inc., San Diego, CA, USA).
    GraphPad Prism
    suggested: (GraphPad Prism, RRID:SCR_002798)
    GraphPad
    suggested: (GraphPad Prism, RRID:SCR_002798)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.11.25.21266704v1 on medRxiv