Spike protein fusion loop controls SARS-CoV-2 fusogenicity and infectivity

  1. Debnath Pal

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Abstract

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  1. Version published to 10.1016/j.jsb.2021.107713
  2. Version published to 10.1101/2020.07.07.191973v2 on bioRxiv
  3. ScreenIT

    SciScore for 10.1101/2020.07.07.191973: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    NIH rigor criteria are not applicable to paper type.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    The sequences used in this study were downloaded from the NCBI database (URL:http://www.ncbi.nlm.nih.gov).
    URL:http://www.ncbi.nlm.nih.gov
    suggested: (GENSAT at NCBI - Gene Expression Nervous System Atlas, RRID:SCR_003923)
    The multiple sequence alignments were performed using the T-coffee webserver (http://tcoffee.crg.cat/).
    T-coffee
    suggested: (T-Coffee, RRID:SCR_011818)
    The secondary structure was calculated by the SECSTR program from the PROCHECK suite (https://www.ebi.ac.uk/thornton-srv/software/PROCHECK/).
    SECSTR
    suggested: (SecStr, RRID:SCR_006220)
    All cartoon diagrams and surfaces were rendered by the PyMol software.
    PyMol
    suggested: (PyMOL, RRID:SCR_000305)
    The molecular dynamics simulations were performed with GROMACS software (43) (http://www.gromacs.org).
    GROMACS
    suggested: (GROMACS, RRID:SCR_014565)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: Please consider improving the rainbow (“jet”) colormap(s) used on page 22. At least one figure is not accessible to readers with colorblindness and/or is not true to the data, i.e. not perceptually uniform.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • No funding statement was detected.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  4. Version published to 10.1101/2020.07.07.191973v1 on bioRxiv