Epidemiological feature, viral shedding, and antibody seroconversion among asymptomatic SARS-CoV-2 carriers and symptomatic/presymptomatic COVID-19 patients

  1. Yi Chen
  2. Ping Li
  3. Yibo Ding
  4. Miao Liu
  5. Leijie Liu
  6. Bo Yi
  7. Ting Wu
  8. Hongjun Dong
  9. Xuying Lao
  10. Keqing Ding
  11. Haibo Wang
  12. Dongliang Zhang
  13. Xiaojie Tan
  14. Zhongfa Wang
  15. Guozhang Xu
  16. Guangwen Cao

Reviewed by

Read the full article

Discuss this preprint

Start a discussion What are Sciety discussions?

Listed in

Log in to save this article

Abstract

No abstract available

Article activity feed

  1. Version published to 10.1016/j.jiph.2021.05.003
  2. Version published to 10.21203/rs.3.rs-131765/v1 on Research Square
  3. ScreenIT

    SciScore for 10.1101/2020.12.18.20248447: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: This study was approved by the Ethics Commissions of Ningbo CDC and Putuo CDC.
    Consent: Written informed consent was waived for emerging infectious diseases
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    Detection of antibodies against SARS-COV-2: IgM and IgG against SARS-CoV-2 in the frozen reserved fasting serum samples were detected using the diagnostic enzyme-linked immunosorbent assay (ELISA) kits.
    SARS-COV-2: IgM
    suggested: None
    Software and Algorithms
    SentencesResources
    The diagnostic kits used for Ningbo patients and Zhoushan patients were manufactured by Innovita Biological Technology (Tangshan, China) and Nanjing Wending Biotech Company (Nanjing, China), respectively [15].
    Innovita Biological Technology
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Our study has some limitations. First, follow-up should be extended to observe the duration of SARS-CoV-2-specific antibodies. Second, sample size of asymptomatic carriers with SARS-CoV-2 infected was relatively small.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  4. Version published to 10.1101/2020.12.18.20248447 on medRxiv