In vivo evaluation of the virucidal efficacy of chlorhexidine and povidone-iodine mouthwashes against salivary SARS-CoV-2. A randomized-controlled clinical trial

  1. Rola Elzein
  2. Fadi Abdel-Sater
  3. Soha Fakhreddine
  4. Pierre Abi Hanna
  5. Rita Feghali
  6. Hassan Hamad
  7. Fouad Ayoub

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Abstract

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  1. Version published to 10.1016/j.jebdp.2021.101584
  2. ScreenIT

    SciScore for 10.1101/2021.03.07.21252302: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: Ethical approval: Ethical clear of this research was delivered from the Lebanese University Institutional Review Board (#CUER 13-2020).
    Consent: All participants were informed about the study and gave their consent.
    RandomizationSampling: Participants were randomly divided into the three groups.
    BlindingTrial design: This study was a parallel group, quadruple blind-randomized-placebo-controlled clinical trial with an add on laboratory based study.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    RNA was extracted from the clinical samples on Kingfisher flex purification system Thermo Fisher using MagMAX(tm) Viral/Pathogen Nucleic Acid Isolation Kit (thermos fisher).
    Thermo Fisher using MagMAX(tm
    suggested: None
    31

    Statistical Analysis: The analysis of data was carried out using GraphPad Prism version 5 for Windows (GraphPad Software, La Jolla California USA, www.graphpad.com).

    GraphPad Prism
    suggested: (GraphPad Prism, RRID:SCR_002798)
    GraphPad
    suggested: (GraphPad Prism, RRID:SCR_002798)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.03.07.21252302v1 on medRxiv