Evaluation of the efficacy of ultra-fractioned and winterized lentisk oil in reducing symptoms of purulent bacterial overinfection of pediatric rhinitis

Acute purulent rhinitis in children has a shorter course and milder symptoms if treated with antibiotics. Antibiotic use, in addition to fueling antibiotic resistance, frequently causes gastrointestinal symptoms. Specific fractions of winterized lentisk oil (Pistacea lentiscus) have demonstrated unique antibiofilm and antibiotic activity against nasal and oropharyngeal pathogens potentially implicated in the symptoms of purulent rhinitis in children. In a randomized, prospective, controlled and no profit trial, the use of a class II medical device, formulated as oil drops for nasal use, containing as active ingredient a ultra-fractioned and winterized lentisk oil (UWLO) and administered for six days, demonstrated the ability to significantly reduce symptoms such as mucous rhinitis, retropharyngeal mucous discharge, halitosis, stuffy nose, and nocturnal catarrhal cough compared to treatment with isotonic saline nasal wash. The use of UWLO also tended to reduce the need for antibiotic therapy and was well tolerated and free of side effects. The data obtained suggest the use of the lentisk derivative to reduce the duration of the clinical course and the main symptoms characterizing pediatric purulent mucosa.