Clinical outcomes in individuals hospitalized with SARS-CoV-2 Delta variant (B.1.617.2) who had been vaccinated with Covishield (ChAdOx1) and Covaxin (BBV-152)

  1. Apoorva Munigela
  2. Divya Tej Sowpati
  3. Sasikala M
  4. Sofia Banu
  5. Archana Bharadwaj Siva
  6. Jagadeesh Kumar V
  7. Chandrasekhar Nutalapati
  8. Ravikanth Vishnubhotla
  9. Anand Kulkarni
  10. Payel Mukherjee
  11. Lamuk Zaveri
  12. G.V. Rao
  13. Karthik Bharadwaj Tallapaka
  14. D. Nageshwar Reddy

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Abstract

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  1. Version published to 10.1016/j.ijregi.2022.08.016
  2. ScreenIT

    SciScore for 10.1101/2021.07.13.21260417: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: The study was approved by the Ethics committee of AIG Hospitals & CSIR-CCMB and the informed consent was waived.
    Consent: The study was approved by the Ethics committee of AIG Hospitals & CSIR-CCMB and the informed consent was waived.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Data processing: Base calling was performed on raw image data using bcl2fastq v2.20.0.422 (Illumina).
    bcl2fastq
    suggested: (bcl2fastq , RRID:SCR_015058)
    FASTQC v0.11.9 (7) was used to assess the quality of reads.
    FASTQC
    suggested: (FastQC, RRID:SCR_014583)
    Trimmomatic was used to trim poor quality bases and adapter sequences (8).
    Trimmomatic
    suggested: (Trimmomatic, RRID:SCR_011848)
    Mapping of reads to the indexed reference genome NC_045512.2 was done using HISAT2 v2.1.0 (9).
    HISAT2
    suggested: (HISAT2, RRID:SCR_015530)
    Coverage across the genome was calculated using samtools depth.
    samtools
    suggested: (SAMTOOLS, RRID:SCR_002105)
    Data was visualized using the ggplot2 package in R.
    ggplot2
    suggested: (ggplot2, RRID:SCR_014601)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.07.13.21260417v1 on medRxiv