Reduced inflammatory responses to SARS-CoV-2 infection in children presenting to hospital with COVID-19 in China

  1. Guoqing Qian
  2. Yong Zhang
  3. Yang Xu
  4. Weihua Hu
  5. Ian P. Hall
  6. Jiang Yue
  7. Hongyun Lu
  8. Liemin Ruan
  9. Maoqing Ye
  10. Jin Mei

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Abstract

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  1. Version published to 10.1016/j.eclinm.2021.100831
  2. ScreenIT

    SciScore for 10.1101/2020.07.02.20145110: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: This study was conducted in accordance with the Declaration of Helsinki and was reviewed and approved by the Medical Ethical Committees (2020-R120).
    Consent: Due to the urgent need to collect data on this emerging infectious disease, the requirement for written informed consent was waived.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    All analyses were analysed using IBM SPSS statistics version 26.0.
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    This study has some limitations. First, this is a retrospective and observational study using pre-existing electronic medical record data. Second, there are relatively few children with severe disease due to COVID-19 and so we may have missed small differences in cytokine levels or cellular responses between the groups with different disease severity. Finally, we did not have measures of viral load and hence cannot take this into account in our analyses. Nonetheless, we show convincingly that the majority of children with COVID19 admitted to hospital have a good outcome unless they have significant co-morbidities, and that this may in part be due to the failure of younger patients to mount a major cytokine response to the SARS-CoV-2.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.07.02.20145110v1 on medRxiv