Evolution of antibody responses up to 13 months after SARS-CoV-2 infection and risk of reinfection
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SciScore for 10.1101/2021.05.07.21256823: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: The protocol was approved by the institutional review board of CPP Sud Méditerranée III.
Consent: All participants provided a written informed consent.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources All except six RT-PCR positive samples were analyzed in our laboratory with SARS-CoV-2 specific primers and probes targeting two regions on the viral RNA-dependent RNA polymerase (RdRp) gene (Institut Pasteur, Paris, France; WHO technical guidance). SARS-CoV-2suggested: (BioLegend Cat# 944703, RRID:AB_2890874)All other data were analyzed and represented using Graphpad … SciScore for 10.1101/2021.05.07.21256823: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: The protocol was approved by the institutional review board of CPP Sud Méditerranée III.
Consent: All participants provided a written informed consent.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources All except six RT-PCR positive samples were analyzed in our laboratory with SARS-CoV-2 specific primers and probes targeting two regions on the viral RNA-dependent RNA polymerase (RdRp) gene (Institut Pasteur, Paris, France; WHO technical guidance). SARS-CoV-2suggested: (BioLegend Cat# 944703, RRID:AB_2890874)All other data were analyzed and represented using Graphpad Prism version 9.0.0. Graphpad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Although our study provides crucial data on the natural history of mild COVID-19, it is important to note that there are some limitations. Neutralization experiments were performed on a small subset of the cohort due to insufficient volume of remaining sera. However, the strong correlation between CMIA IgG levels and neutralizing titers observed in this study, and reported by the manufacturer as well as by other studies(15, 33, 34), allows an extrapolation of the results to the entire cohort. Assessment of reinfection was based on participant reports during visits, as no RT-PCR surveillance was planned in the study. Therefore, it cannot be excluded that the COVID-19 positive participants had unnoticed asymptomatic reinfection during follow-up. However, no COVID-19 positive HCW, except the case of reinfection, had a significant increase of both anti-S and anti-N levels during follow-up. Another limitation is the unbalanced sex distribution, with a female predominance, which reflects the sex distribution of the healthcare workers in our hospital. Nevertheless, the sex difference in immune response was observed by using univariate and multivariate analysis. Furthermore, we were not able to investigate the kinetics of memory B cells because of the lack of peripheral blood mononuclear cells. Finally, our results were obtained in participants with a median age of 39 years (IQR 30-51), hence we cannot exclude that older individuals may experience a different evolution of humoral res...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04441684 Recruiting Seroprevalence of SARS-CoV-2 in Strasbourg University Hospit… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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