SARS-CoV-2 IgG antibody responses in New York City

  1. Josh Reifer
  2. Nosson Hayum
  3. Benzion Heszkel
  4. Ikey Klagsbald
  5. Vincent A. Streva

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Abstract

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  1. Version published to 10.1016/j.diagmicrobio.2020.115128
  2. ScreenIT

    SciScore for 10.1101/2020.05.23.20111427: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    This assay is an FDA EUA diagnostic test for the qualitative detection of SARS-CoV-2 IgG antibodies but produces a numerical index value (in arbitrary units per milliliter) which is indicative of the intensity of the reaction, and therefore a surrogate for SARS-CoV-2 IgG antibody levels.
    SARS-CoV-2 IgG
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    One potential limitation of our study, is the potential for waning immunity in the weeks after infection. The patient cohort used to correlate SSI to SARS-CoV-2 antibody levels were from a single tight-knit community in the Boro Park neighborhood of Brooklyn, and were epidemiologically determined to have had exposure or expected exposure to SARS-CoV-2 eight to twelve weeks prior to presenting for SARS-CoV-2 IgG testing. While we cannot entirely rule out alternative time-courses of infection in all patients, the clinical and epidemiological data gathered suggest all patients in the SSI cohort were infected by SARS-CoV-2 within approximately two weeks of one another. From the larger sample of 28,523 patients, we do not have access to sufficient epidemiological data to conclusively determine suspected dates of exposure to SARS-CoV-2. Future work will be needed to track SARS-CoV-2 IgG antibody levels over time. The findings of our study have additional implications for blood banks seeking donors for convalescent plasma to treat Covid-19 patients. These facilities have traditionally screened donors for antibodies using qualitative antibody tests and have often relied on self-reporting by patients of their history and timing of symptoms to support a previous diagnosis of SARS-CoV-2. The availability of a semi-quantitative SARS-CoV-2 IgG assay with index values that correlate to severity of past infection could prove to be of significant help in selecting plasma donors. Additional s...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.05.23.20111427 on medRxiv