Robustness of epithelial sealing is an emerging property of local ERK feedback driven by cell elimination

  1. Léo Valon
  2. Anđela Davidović
  3. Florence Levillayer
  4. Alexis Villars
  5. Mathilde Chouly
  6. Fabiana Cerqueira-Campos
  7. Romain Levayer

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Abstract

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  1. Version published to 10.1016/j.devcel.2021.05.006
  2. Version published to 10.1101/2020.03.17.994921v2 on bioRxiv
  3. preLights

    Excerpt

    Epithelium on damage control mode: a transitory local feedback loop in response to cell elimination prevents neighbor cell death to ensure tissue sealing.

  4. preLights

    Excerpt

    How do epithelia regulate cell elimination to remain intact? Using recently developed in vivo tools, Valon et al. find that extruding cells protect their immediate neighbors from elimination via an EGFR-dependent process.

  5. Version published to 10.1101/2020.03.17.994921v1 on bioRxiv