Mechanosensing through Direct Binding of Tensed F-Actin by LIM Domains

  1. Xiaoyu Sun
  2. Donovan Y.Z. Phua
  3. Lucas Axiotakis
  4. Mark A. Smith
  5. Elizabeth Blankman
  6. Rui Gong
  7. Robert C. Cail
  8. Santiago Espinosa de los Reyes
  9. Mary C. Beckerle
  10. Clare M. Waterman
  11. Gregory M. Alushin

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Abstract

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  1. Version published to 10.1016/j.devcel.2020.09.022
  2. preLights

    Excerpt

    Can molecular signatures within cells reveal mechanical stress? How are they recognised? Two preprints present evidence that actin filaments under duress may relay the message by directly recruiting multi-contextual LIM domains.

  3. Version published to 10.1101/2020.03.06.979245v1 on bioRxiv