SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity

  1. Chihiro Motozono
  2. Mako Toyoda
  3. Jiri Zahradnik
  4. Akatsuki Saito
  5. Hesham Nasser
  6. Toong Seng Tan
  7. Isaac Ngare
  8. Izumi Kimura
  9. Keiya Uriu
  10. Yusuke Kosugi
  11. Yuan Yue
  12. Ryo Shimizu
  13. Jumpei Ito
  14. Shiho Torii
  15. Akiko Yonekawa
  16. Nobuyuki Shimono
  17. Yoji Nagasaki
  18. Rumi Minami
  19. Takashi Toya
  20. Noritaka Sekiya
  21. Takasuke Fukuhara
  22. Yoshiharu Matsuura
  23. Gideon Schreiber
  24. Terumasa Ikeda
  25. So Nakagawa
  26. Takamasa Ueno
  27. Kei Sato

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Abstract

No abstract available

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  3. Version published to 10.1016/j.chom.2021.06.006
  4. ScreenIT

    SciScore for 10.1101/2021.04.02.438288: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    KEY RESOURCES TABLE: RESOURCE AVAILABILITY: EXPERIMENTAL MODEL AND SUBJECT DETAILS: METHOD DETAILS: QUANTIFICATION AND STATISTICAL ANALYSIS: Data analyses were performed using Prism 7 (GraphPad Software).
    Prism
    suggested: (PRISM, RRID:SCR_005375)
    GraphPad
    suggested: (GraphPad Prism, RRID:SCR_002798)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    A limitation of this study is that the effects of the L452 and Y453 substitutions on viral pathogenicity, mortality and transmissibility remain unaddressed. To fully characterize the virological features of these mutants, further investigations using animal models and epidemiological data will be required. Nevertheless, here we showed direct evidence suggesting that the mutations in the RBM including L452R (in the B.1.427/429 lineage) and Y453F (in the B1.1.298 lineage) potentially escape from the HLA-A24-resticted cellular immunity, and further, the L452R mutant increase its replication capacity. Therefore, these variants, particularly those possessing the L452R mutations, such as the B.1.427/429 lineage, can be the potential threat for these countries and regions with predominant HLA-A24 individuals, and deep surveillance and tracing the epidemic of these variants will be urgently required.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  5. Version published to 10.1101/2021.04.02.438288v1 on bioRxiv