ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection

  1. Furong Liu
  2. Xin Long
  3. Bixiang Zhang
  4. Wanguang Zhang
  5. Xiaoping Chen
  6. Zhanguo Zhang

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Abstract

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  1. Version published to 10.1016/j.cgh.2020.04.040
  2. ScreenIT

    SciScore for 10.1101/2020.02.28.20029181: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    The annotation of cell types was completed based on the featured genes of each cluster and the cell markers of each type pancreas cell from CellMarker database[11] and previously report[8, 9].
    CellMarker
    suggested: (CellMarker, RRID:SCR_018503)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    In our study, there are still some limitations. There is no direct evidence that the slight damage to the pancreas was caused by SARS-COV-2 binding to ACE2 in the pancreas, and no studies have shown that nucleic acids of SARS-COV-2 have been detected in the pancreas. Due to the particularity of the location of the pancreas, this study could not be carried out. At present, the body anatomy has been conducted in China, and we hope to see this result in the future. At the same time, the systemic inflammatory response in severe COVID-19 patients might also cause mild damage to the pancreas. However, in the causes of pancreatitis, virus infection factors such as mumps, herpes simplex virus should not be ignored[18]. Our study provides a new idea and a possible mechanism.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.02.28.20029181 on medRxiv