Multisystem inflammatory syndrome in children related to COVID-19: a systematic review

  1. Levi Hoste
  2. Ruben Van Paemel
  3. Filomeen Haerynck

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Abstract

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  1. Version published to 10.1007/s00431-021-03993-5
  2. ScreenIT

    SciScore for 10.1101/2020.08.17.20173641: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Electronic databases were searched (PubMed, Embase), including pre-print (BioRxiv, MedRxiv) and COVID-19-specific research repositories (Cochrane COVID-19 Study Register and WHO COVID-19 Global Research Database).
    PubMed
    suggested: (PubMed, RRID:SCR_004846)
    BioRxiv
    suggested: (bioRxiv, RRID:SCR_003933)

    Results from OddPub: Thank you for sharing your code and data.

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Ultimately, this review has several limitations. In particular, we were unable to collect individual data of all patients and the single case data are obtained from case reports and case series. We did not contact the authors of included studies for additional information or insights in their data as we believed this would significantly delay the reporting of this pressing data. Due to the nature of included studies, these reports are moreover enriched for severe disease course (e.g. shock being more frequent in single cases than cohorts). Furthermore, only two15,43 of the included studies contain a historical control population. In addition, the initial association of COVID-19 could have triggered a reporting bias. It is reasonable that this might result in overdiagnosis of PIMS-TS/MIS(-C), which can be appreciated from the single case proportions meeting the different case definitions. The sensitivity and specificity of recognized case definitions should prospectively be assessed. This review currently favors the use of the WHO MIS definition, being specific (e.g. concerning the association with COVID-19), while remaining 98% sensitive. In future studies, we furthermore recommend including a control population with similar disease characteristics in whom a recent or close contact with COVID-19 is excluded, in order to further characterize PIMS-TS/MIS(-C). As this review was conducted while PIMS-TS/MIS(-C) has only been described since a few months, inevitably, delayed compl...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a protocol registration statement.

    About SciScore

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  3. Version published to 10.1101/2020.08.17.20173641v1 on medRxiv
  4. Version published to 10.1101/2020.08.17.20173641v2 on medRxiv