Trajectory of Viral RNA Load Among Persons With Incident SARS-CoV-2 G614 Infection (Wuhan Strain) in Association With COVID-19 Symptom Onset and Severity

  1. Helen C. Stankiewicz Karita
  2. Tracy Q. Dong
  3. Christine Johnston
  4. Kathleen M. Neuzil
  5. Michael K. Paasche-Orlow
  6. Patricia J. Kissinger
  7. Anna Bershteyn
  8. Lorna E. Thorpe
  9. Meagan Deming
  10. Angelica Kottkamp
  11. Miriam Laufer
  12. Raphael J. Landovitz
  13. Alfred Luk
  14. Risa Hoffman
  15. Pavitra Roychoudhury
  16. Craig A. Magaret
  17. Alexander L. Greninger
  18. Meei-Li Huang
  19. Keith R. Jerome
  20. Mark Wener
  21. Connie Celum
  22. Helen Y. Chu
  23. Jared M. Baeten
  24. Anna Wald
  25. Ruanne V. Barnabas
  26. Elizabeth R. Brown

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Abstract

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  1. Version published to 10.1001/jamanetworkopen.2021.42796
  2. ScreenIT

    SciScore for 10.1101/2021.08.27.21262754: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: The Western Institutional Review Board approved the trial; all participants provided informed consent.
    Consent: The Western Institutional Review Board approved the trial; all participants provided informed consent.
    Field Sample Permit: The participant placed the swab in a collection tube containing 1mL of phosphate-buffered saline, and such specimens were shipped to the University of Washington (UW) every 5-7 days.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    28 Participants completed daily symptom questionnaires using REDCap.
    REDCap
    suggested: (REDCap, RRID:SCR_003445)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.08.27.21262754v1 on medRxiv