Evaluated articles

Trackosome: a computational toolbox to study the spatiotemporal dynamics of centrosomes, nuclear envelope and cellular membrane

1. Domingos Castro
2. Vanessa Nunes
3. Joana T. Lima
4. Jorge G. Ferreira
5. Paulo Aguiar

Reviewed by preLights

Distinct RopGEFs Successively Drive Polarization and Outgrowth of Root Hairs

1. Philipp Denninger
2. Anna Reichelt
3. Vanessa A.F. Schmidt
4. Dietmar G. Mehlhorn
5. Lisa Y. Asseck
6. Claire E. Stanley
7. Nana F. Keinath
8. Jan-Felix Evers
9. Christopher Grefen
10. Guido Grossmann

Reviewed by preLights

Species-specific developmental timing is associated with global differences in protein stability in mouse and human

1. Teresa Rayon
2. Despina Stamataki
3. Ruben Perez-Carrasco
4. Lorena Garcia-Perez
5. Christopher Barrington
6. Manuela Melchionda
7. Katherine Exelby
8. Victor Tybulewicz
9. Elizabeth M. C. Fisher
10. James Briscoe

Reviewed by preLights

Recognition of RNA by the S9.6 antibody creates pervasive artifacts when imaging RNA:DNA hybrids

1. John A. Smolka
2. Lionel A. Sanz
3. Stella R. Hartono
4. Frédéric Chédin

Reviewed by preLights

Aerobic glycolysis is important for zebrafish larval wound closure and tail regeneration

1. Claire A. Scott
2. Tom J. Carney
3. Enrique Amaya

Reviewed by preLights

Three-axis classification of mouse lung mesenchymal cells reveals two populations of myofibroblasts

1. Odemaris Narvaez del Pilar
2. Maria Jose Gacha Garay
3. Jichao Chen

Reviewed by preLights

Self-generated gradients steer collective migration on viscoelastic collagen networks

1. Andrew G. Clark
2. Ananyo Maitra
3. Cécile Jacques
4. Martin Bergert
5. Carlos Pérez-González
6. Anthony Simon
7. Luc Lederer
8. Alba Diz-Muñoz
9. Xavier Trepat
10. Raphaël Voituriez
11. Danijela Matic Vignjevic

Reviewed by preLights

Antiviral activity of bacterial TIR domains via immune signalling molecules

1. Gal Ofir
2. Ehud Herbst
3. Maya Baroz
4. Daniel Cohen
5. Adi Millman
6. Shany Doron
7. Nitzan Tal
8. Daniel B. A. Malheiro
9. Sergey Malitsky
10. Gil Amitai
11. Rotem Sorek

Reviewed by preLights

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

1. Sherine E Thomas
2. Andrew J Whitehouse
3. Karen Brown
4. Sophie Burbaud
5. Juan M Belardinelli
6. Jasper Sangen
7. Ramanuj Lahiri
8. Mark Daben J Libardo
9. Pooja Gupta
10. Sony Malhotra
11. Helena I M Boshoff
12. Mary Jackson
13. Chris Abell
14. Anthony G Coyne
15. Tom L Blundell
16. Rodrigo Andres Floto
17. Vítor Mendes

Reviewed by preLights

Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex

1. Nora Jamann
2. Dominik Dannehl
3. Nadja Lehmann
4. Robin Wagener
5. Corinna Thielemann
6. Christian Schultz
7. Jochen Staiger
8. Maarten H. P. Kole
9. Maren Engelhardt

Reviewed by preLights

Microtissue Geometry and Cell‐Generated Forces Drive Patterning of Liver Progenitor Cell Differentiation in 3D

1. Ian C. Berg
2. Erfan Mohagheghian
3. Krista Habing
4. Ning Wang
5. Gregory H. Underhill

Reviewed by preLights

Lineage recording reveals dynamics of cerebral organoid regionalization

1. Zhisong He
2. Tobias Gerber
3. Ashley Maynard
4. Akanksha Jain
5. Rebecca Petri
6. Malgorzata Santel
7. Kevin Ly
8. Leila Sidow
9. Fátima Sanchís-Calleja
10. Stephan Riesenberg
11. J. Gray Camp
12. Barbara Treutlein

Reviewed by preLights

N-cadherin stabilises neural identity by dampening anti-neural signals

1. K Punovuori
2. RP Migueles
3. M Malaguti
4. G Blin
5. KG Macleod
6. NO Carragher
7. T Pieters
8. F van Roy
9. MP Stemmler
10. S Lowell

Reviewed by preLights

Role for the flagellum attachment zone in Leishmania anterior cell tip morphogenesis

1. Clare Halliday
2. Ryuji Yanase
3. Carolina Moura Costa Catta-Preta
4. Flavia Moreira-Leite
5. Jitka Myskova
6. Katerina Pruzinova
7. Petr Volf
8. Jeremy C. Mottram
9. Jack D. Sunter

Reviewed by preLights

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

1. Theodore L. Roth
2. P. Jonathan Li
3. Jasper F. Nies
4. Ruby Yu
5. Michelle L.T. Nguyen
6. Youjin Lee
7. Ryan Apathy
8. Anna Truong
9. Joseph Hiatt
10. David Wu
11. David N. Nguyen
12. Daniel Goodman
13. Jeffrey A. Bluestone
14. Kole Roybal
15. Eric Shifrut
16. Alexander Marson

Reviewed by preLights

An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase

1. Goutam Mukherjee
2. Prajwal P. Nandekar
3. Rebecca C. Wade

Reviewed by preLights

Sick Bats Stay Home Alone: Social distancing during the acute phase response in Egyptian fruit bats ( Rousettus aegyptiacus )

1. Kelsey R. Moreno
2. Maya Weinberg
3. Lee Harten
4. Valeria B. Salinas Ramos
5. L. Gerardo Herrera M.
6. Gábor Á. Czirják
7. Yossi Yovel

Reviewed by preLights

LTK is an ER-resident receptor tyrosine kinase that regulates secretion

1. Federica G. Centonze
2. Veronika Reiterer
3. Karsten Nalbach
4. Kota Saito
5. Krzysztof Pawlowski
6. Christian Behrends
7. Hesso Farhan

Reviewed by preLights

Establishment of the mayfly Cloeon dipterum as a new model system to investigate insect evolution

1. Isabel Almudi
2. Carlos A. Martín-Blanco
3. Isabel M. García-Fernandez
4. Adrián López-Catalina
5. Kristofer Davie
6. Stein Aerts
7. Fernando Casares

Reviewed by preLights

Humans optimally anticipate and compensate for an uneven step during walking

1. Osman Darici
2. Arthur D Kuo

• Curated by eLife

  Evaluation Summary:

  This study provides experimental evidence supporting an energy optimality principle for walking over uneven terrain. Using a simple rimless wheel model of human walking, the authors previously predicted speed fluctuations to emerge when a step up or down when energy is minimized over the entire walking path. New experimental evidence provides evidence that both anticipatory and reactive adjustments used by the nervous system follow the predictions of an energy minimization principle. The predictive power of an energy-minimization principle during transient, non-steady state behavior is notable. Certain issues regarding the generalizability of the results to variable step lengths and timing, alternative optimality criteria, and limitations of the modeling assumptions should be clarified.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife, preLights