Evaluated articles

The Nt17 Domain and its Helical Conformation Regulate the Aggregation, Cellular Properties and Neurotoxicity of Mutant Huntingtin Exon 1

1. Sophie Vieweg
2. Anne-Laure Mahul-Mellier
3. Francesco S. Ruggeri
4. Nathan Riguet
5. Sean M. DeGuire
6. Anass Chiki
7. Urszula Cendrowska
8. Giovanni Dietler
9. Hilal A. Lashuel

Reviewed by Review Commons

Differential gene regulation in DAPT-treated Hydra reveals candidate direct Notch signalling targets

1. Jasmin Moneer
2. Stefan Siebert
3. Stefan Krebs
4. Jack Cazet
5. Andrea Prexl
6. Qin Pan
7. Celina Juliano
8. Angelika Böttger

Reviewed by Review Commons

Automated morphometric analysis with SMorph software reveals plasticity induced by antidepressant therapy in hippocampal astrocytes

1. Parul Sethi
2. Garima Virmani
3. Kushaan Gupta
4. Surya Chandra Rao Thumu
5. Narendrakumar Ramanan
6. Swananda Marathe

Reviewed by Review Commons

Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis

1. Nadja Kern
2. Rui Dong
3. Shawn M Douglas
4. Ronald D Vale
5. Meghan A Morrissey

Reviewed by Review Commons, preLights

Striking parallels between dorsoventral patterning in Drosophila and Gryllus reveal a complex evolutionary history behind a model gene regulatory network

1. Matthias Pechmann
2. Nathan James Kenny
3. Laura Pott
4. Peter Heger
5. Yen-Ta Chen
6. Thomas Buchta
7. Orhan Özüak
8. Jeremy Lynch
9. Siegfried Roth

Reviewed by Review Commons

CDK4/6 inhibitors induce replication stress to cause long‐term cell cycle withdrawal

1. Lisa Crozier
2. Reece Foy
3. Brandon L Mouery
4. Robert H Whitaker
5. Andrea Corno
6. Christos Spanos
7. Tony Ly
8. Jeanette Gowen Cook
9. Adrian T Saurin

Reviewed by Review Commons

Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration

1. Abigail H. Cleveland
2. Alejandra Romero-Morales
3. Laurent Alfonso Azcona
4. Melisa Herrero
5. Viktoriya D. Nikolova
6. Sheryl Moy
7. Orna Elroy-Stein
8. Vivian Gama
9. Timothy R. Gershon

Reviewed by Review Commons

Functional visualization of NK cell-mediated killing of metastatic single tumor cells

1. Hiroshi Ichise
2. Shoko Tsukamoto
3. Tsuyoshi Hirashima
4. Yoshinobu Konishi
5. Choji Oki
6. Shinya Tsukiji
7. Satoshi Iwano
8. Atsushi Miyawaki
9. Kenta Sumiyama
10. Kenta Terai
11. Michiyuki Matsuda

Reviewed by Review Commons

Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

1. Evgeniya Trofimenko
2. Gianvito Grasso
3. Mathieu Heulot
4. Nadja Chevalier
5. Marco A Deriu
6. Gilles Dubuis
7. Yoan Arribat
8. Marc Serulla
9. Sebastien Michel
10. Gil Vantomme
11. Florine Ory
12. Linh Chi Dam
13. Julien Puyal
14. Francesca Amati
15. Anita Lüthi
16. Andrea Danani
17. Christian Widmann

• Curated by eLife

  Evaluation Summary:

  Although the role of membrane potential in Cell Permeable Peptides (CPP) translocation has been consistently described in artificial systems, this multi scale study, combining cell biology, genetics and in silico approaches, further extends this topic to a live cell context where it shows that internalization stops when the membrane polarization is decreased by the removal of potassium channels. It proposes an original mechanism of CPP translocation based on water pore formation, which should be of interest for biophysicists, cell biologists and for applications such as drug delivery.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife, Review Commons

Multiscale analysis of single and double maternal-zygotic Myh9 and Myh10 mutants during mouse preimplantation development

1. Markus Frederik Schliffka
2. Anna Francesca Tortorelli
3. Özge Özgüç
4. Ludmilla de Plater
5. Oliver Polzer
6. Diane Pelzer
7. Jean-Léon Maître

Reviewed by Review Commons

Glucocorticoid signaling induces transcriptional memory and universally reversible chromatin changes

1. Melissa Bothe
2. René Buschow
3. Sebastiaan H Meijsing

Reviewed by Review Commons

Distinct spermiogenic phenotypes underlie sperm elimination in the Segregation Distorter meiotic drive system

1. Marion Herbette
2. Xiaolu Wei
3. Ching-Ho Chang
4. Amanda M. Larracuente
5. Benjamin Loppin
6. Raphaëlle Dubruille

Reviewed by Review Commons

Single mosquito metatranscriptomics identifies vectors, emerging pathogens and reservoirs in one assay

1. Joshua Batson
2. Gytis Dudas
3. Eric Haas-Stapleton
4. Amy L Kistler
5. Lucy M Li
6. Phoenix Logan
7. Kalani Ratnasiri
8. Hanna Retallack

Reviewed by Review Commons

Somatic drift and rapid loss of heterozygosity suggest small effective population size of stem cells and high somatic mutation rate in asexual planaria

1. Hosseinali Asgharian
2. Joseph Dunham
3. Paul Marjoram
4. Sergey V. Nuzhdin

Reviewed by Review Commons

Wnt/beta-catenin signalling is dispensable for adult neural stem cell homeostasis and activation

1. Sophie H. L. Austin
2. Rut Gabarró-Solanas
3. Piero Rigo
4. Oana Paun
5. Lachlan Harris
6. François Guillemot
7. Noelia Urbán

Reviewed by Review Commons

Stepwise transmigration of T- and B cells through a perivascular channel in high endothelial venules

1. Kibaek Choe
2. Jieun Moon
3. Soo Yun Lee
4. Eunjoo Song
5. Ju Hee Back
6. Joo-Hye Song
7. Young-Min Hyun
8. Kenji Uchimura
9. Pilhan Kim

Reviewed by Review Commons

A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within Saccharomyces cerevisiae

1. Pengyao Jiang
2. Anja R Ollodart
3. Vidha Sudhesh
4. Alan J Herr
5. Maitreya J Dunham
6. Kelley Harris

Reviewed by Review Commons

Transcriptomic entropy benchmarks stem cell-derived cardiomyocyte maturation against endogenous tissue at single cell level

1. Suraj Kannan
2. Michael Farid
3. Brian L. Lin
4. Matthew Miyamoto
5. Chulan Kwon

Reviewed by Review Commons

The Drosophila Baramicin polypeptide gene protects against fungal infection

1. Mark Austin Hanson
2. Lianne B. Cohen
3. Alice Marra
4. Igor Iatsenko
5. Steven A. Wasserman
6. Bruno Lemaitre

Reviewed by Review Commons

The trypanosome Variant Surface Glycoprotein mRNA is stabilized by an essential unconventional RNA-binding protein

1. Larissa Melo do Nascimento
2. Franziska Egler
3. Katharina Arnold
4. Nina Papavisiliou
5. Christine Clayton
6. Esteban Erben

Reviewed by Review Commons