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  1. Genome assembly of the hybrid grapevine Vitis ‘Chambourcin’

    This article has 5 authors:
    1. Sagar Patel
    2. Zachary N. Harris
    3. Jason P. Londo
    4. Allison Miller
    5. Anne Fennell
    This article has been curated by 1 group:
    • Curated by GigaByte

      Editor’s Assessment

      Hybrid genomes are tricky to assemble, and few genomic resources are available for hybrid grapevines such as ‘Chambourcin’, a French-American interspecific hybrid grape grown in the eastern and midwestern United States. Here is an attempt to assemble Chambourcin’ using a combination of PacBio HiFi long-reads, Bionano optical maps, and Illumina short-read sequencing technologies. Producing an assembly with 26 scaffolds, an N50 length 23.3 Mb and an estimated BUSCO completeness of 97.9% that can be used for genome comparisons, functional genomic analyses, and genome-assisted breeding research. Error correction and pilon polishing was a challenge with this hybrid assembly, but after trying a few different approaches in the review process have improved it, and as they have documented what they did and are clear about the final metrics, users can assess the quality themselves.

      This assessment refers to version 2 of this preprint.

    Reviewed by GigaByte

    This article has 2 evaluationsAppears in 4 listsLatest version Latest activity
  2. Trumpet plots: Visualizing The Relationship Between Allele Frequency And Effect Size In Genetic Association Studies

    This article has 4 authors:
    1. Lucia Corte
    2. Lathan Liou
    3. Paul F. O’Reilly
    4. Judit García-González
    This article has been curated by 1 group:
    • Curated by GigaByte

      **Editors Assessment: **

      This work presents a new standardized graphical approach for visualizing genetic associations across a wide range of allele frequencies. These proposed TrumpetPlots have a distinctive trumpet shape, hence the proposed name. With the majority of variants having low frequency and small effects, while a small number of variants have higher frequency and larger effects, this view can help to provide new and valuable insights into the genetic basis of traits and diseases, and also help prioritize efforts to discover new risk variants. The tool is provided as a novel R package and R Shiny application and to demonstrate its use the article illustrates the distribution of variant effect sizes across the allele frequency range for over 100 continuous traits available in the UK Biobank. After some problems in testing the package is now available and easy to deploy via CRAN.

      *This assessment refers to version 1 of this preprint. *

    Reviewed by GigaByte

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity

    Scott C Edmunds

    If you look at the figures in the peer reviewed and published version in GigaByte journal there are interactive figures that demonstrate the graphic outputs of the tool.

    See the updated Figure 1 here:

    https://gigabytejournal.com/articles/89/assets/figure-1.html