Reading List

Mechanisms of urate transport and uricosuric drugs inhibition in human URAT1

1. Wenjun Guo
2. Miao Wei
3. Yunfeng Li
4. Jiaxuan Xu
5. Jiahe Zang
6. Yuezhou Chen
7. Lei Chen

Structural basis of the excitatory amino acid transporter 3 substrate recognition

1. Biao Qiu
2. Olga Boudker

Allosteric modulation of proton binding confers Cl ^- activation and glutamate selectivity to vesicular glutamate transporters

1. Bart Borghans
2. Daniel Kortzak
3. Piersilvio Longo
4. Jan-Philipp Machtens
5. Christoph Fahlke

A novel mechanism for the uptake of enterobactin-chelated ferric ions by the mitochondria and subsequent reduction to ferrous ions inside

1. Abeg Dutta
2. Anutthaman Parthasarathy
3. Namasivayam Ganesh Pandian

Resolving the conformational ensemble of a membrane protein by integrating small-angle scattering with AlphaFold

1. Samuel Eriksson Lidbrink
2. Rebecca Howard
3. Nandan Haloi
4. Erik Lindahl

AI-based discovery and cryoEM structural elucidation of a KATP channel pharmacochaperone

1. Assmaa Elsheikh
2. Camden M Driggers
3. Ha H Truong
4. Zhongying Yang
5. John Allen
6. Niel M Henriksen
7. Katarzyna Walczewska-Szewc
8. Show-Ling Shyng

• Curated by eLife

  eLife Assessment

  This important study demonstrates that screening by artificial intelligence can identify relevant novel compounds for interacting with KATP channels. The experimental work is compelling. The broader significance of this work relates to the possibility that KATP channel mutations linked to congenital hyperinsulinism may be effectively rescued to the cell surface with a drug, which could normalize insulin secretion or enhance the effectiveness of existing KATP channel activators such as diazoxide.

Reviewed by eLife

Transport of herbicides by PIN-FORMED auxin transporters

1. Lukas Schulz
2. Kien Lam Ung
3. Sarah Koutnik-Abele
4. David L Stokes
5. Bjørn Panyella Pedersen
6. Ulrich Z. Hammes

Molecular Insights into Single Chain Lipid Modulation of Acid-Sensing Ion Channel 3

1. Ramya Bandarupalli
2. Rebecca Roth
3. Robert C Klipp
4. John R Bankston
5. Jing Li

Reviewed by Arcadia Science

Comparative analysis of STP6 and STP10 unravels molecular selectivity in Sugar Transport Proteins

1. Camilla Gottlieb Andersen
2. Laust Bavnhøj
3. Søren Brag
4. Anastasiia Bohush
5. Adriana Chrenková
6. Jan Heiner Driller
7. Bjørn Panyella Pedersen

Mammalian PIEZO channels rectify anionic currents

1. Tharaka D. Wijerathne
2. Aashish Bhatt
3. Wenjuan Jiang
4. Yun Lyna Luo
5. Jerome J. Lacroix

Atomic-Level Free Energy Landscape Reveals Cooperative Symport Mechanism of Melibiose Transporter

1. Ruibin Liang
2. Lan Guan

• Curated by eLife

  eLife Assessment

  In this potentially important study, the authors employed advanced computational techniques to explore a detailed atomistic description of the mechanism and energetics of substrate translocation in the MelB transporter. The overall approach is solid and reveals the coupling between sodium binding and melibiose transport through a series of conformational transitions, and the results for a mutant are also in qualitative agreement with the experiment, providing further support to the computational analyses. Nevertheless, the level of evidence is considered incomplete since there are concerns regarding the convergence and initial guess of the string calculations, leaving doubts that the computed pathway does not reflect the most energetically favorable mechanism.

Reviewed by eLife

Structures of Multiple Peptide Resistance Factor from Pseudomonas aeruginosa

1. Shaileshanand Jha
2. Kutti R. Vinothkumar