Reading List

A millisecond coarse-grained simulation approach to decipher allosteric cannabinoid binding at the glycine receptor α 1

1. Alessio Bartocci
2. Andrea Grazzi
3. Nour Awad
4. Pierre-Jean Corringer
5. Paulo C.T. Souza
6. Marco Cecchini

Dissecting the molecular basis for the modulation of neurotransmitter GPCR signaling by GINIP

1. Alex Luebbers
2. Alberto J. Gonzalez-Hernandez
3. Myles Zhou
4. Stephen J. Eyles
5. Joshua Levitz
6. Mikel Garcia-Marcos

Protein-lipid charge interactions control the folding of OMPs into asymmetric membranes

1. Jonathan Machin
2. Antreas C. Kali
3. Neil A. Ranson
4. Sheena E. Radford

High-resolution structure of a mercury cross-linked ZIP metal transporter reveals delicate motions and metal relay for regulated zinc transport

1. Tuo Zhang
2. Yao Zhang
3. Dexin Sui
4. Jian Hu

Uncovering protein-protein interactions of the human sodium channel Nav1.7

1. Xuelong Zhou
2. Jing Zhao

cAMP binding to closed pacemaker ion channels is cooperative

1. Stefan Kuschke
2. Susanne Thon
3. Christian Sattler
4. Tina Schwabe
5. Klaus Benndorf
6. Ralf Schmauder

Barley Nodulin 26-like intrinsic protein permeates water, metalloids, saccharides, and ion pairs due to structural plasticity and diversification

1. Akshayaa Venkataraghavan
2. Julian G. Schwerdt
3. Stephen D. Tyerman
4. Maria Hrmova

Selectivity filter mutations shift ion permeation mechanism in potassium channels

1. Andrei Mironenko
2. Bert L de Groot
3. Wojciech Kopec

Comprehensive Characterization of Endogenous Phospholamban Proteoforms Enabled by Photocleavable Surfactant and Top-down Proteomics

1. Holden T. Rogers
2. David S. Roberts
3. Eli J. Larson
4. Jake A. Melby
5. Kalina J. Rossler
6. Austin V. Carr
7. Kyle A. Brown
8. Ying Ge

A vertebrate-wide catalogue of T1R receptors reveals diversity in taste perception

1. Hidenori Nishihara
2. Yasuka Toda
3. Tae Kuramoto
4. Kota Kamohara
5. Azusa Goto
6. Kyoko Hoshino
7. Shinji Okada
8. Shigehiro Kuraku
9. Masataka Okabe
10. Yoshiro Ishimaru

Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons

1. Jiwon Yi
2. Zachariah Bertels
3. John Smith Del Rosario
4. Allie J. Widman
5. Richard A. Slivicki
6. Maria Payne
7. Henry M. Susser
8. Bryan A. Copits
9. Robert W. Gereau

Retigabine and gabapentin restore channel function and neuronal firing of an epilepsy-associated dominant-negative KCNQ5 variant

1. Johanna Krüger
2. Holger Lerche

Activation and substrate specificity of the human P4-ATPase ATP8B1

1. Thibaud Dieudonné
2. Felix Kümmerer
3. Michelle Juknaviciute Laursen
4. Charlott Stock
5. Rasmus Kock Flygaard
6. Syma Khalid
7. Guillaume Lenoir
8. Joseph A. Lyons
9. Kresten Lindorff-Larsen
10. Poul Nissen

PMIpred: a physics-informed web server for quantitative protein–membrane interaction prediction

1. Niek van Hilten
2. Nino Verwei
3. Jeroen Methorst
4. Carsten Nase
5. Andrius Bernatavicius
6. Herre Jelger Risselada

Real-time tracking of drug binding to influenza A M2 reveals a high energy barrier

1. Kumar Tekwani Movellan
2. Melanie Wegstroth
3. Kerstin Overkamp
4. Andrei Leonov
5. Stefan Becker
6. Loren B. Andreas

Uncovering and engineering the mechanical properties of the adhesion GPCR ADGRG1 GAIN domain

1. L. Dumas
2. M. Marfoglia
3. B. Yang
4. M. Hijazi
5. A.N. Larabi
6. K. Lau
7. F. Pojer
8. M.A. Nash
9. P. Barth

Spatio-temporal dynamics of the proton motive force on single bacterial cells

1. Anaïs Biquet-Bisquert
2. Baptiste Carrio
3. Nathan Meyer
4. Thales F.D. Fernandes
5. Manouk Abkarian
6. Farida Seduk
7. Axel Magalon
8. Ashley L. Nord
9. Francesco Pedaci

The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms

1. Duy Lan Huong Bui
2. Andrew Roach
3. Jingxian Li
4. Sumit J. Bandekar
5. Elizabeth Orput
6. Ritika Raghavan
7. Demet Araç
8. Richard Sando

Attractant and repellent induce opposing changes in the chemoreceptor four-helix bundle ligand-binding domain

1. Lu Guo
2. Yun-Hao Wang
3. Rui Cui
4. Zhou Huang
5. Yuan Hong
6. Jia-Wei Qian
7. Bin Ni
8. An-Ming Xu
9. Cheng-Ying Jiang
10. Igor B. Zhulin
11. Shuang-Jiang Liu
12. De-Feng Li

Exploring the K+ binding site and its coupling to transport in the neurotransmitter:sodium symporter LeuT

1. Solveig G Schmidt
2. Andreas Nygaard
3. Joseph A Mindell
4. Claus J Loland

• Curated by eLife

  eLife assessment

  The bacterial neurotransmitter:sodium symporter homoglogue LeuT is an well-established model system for understanding the fundamental basis for how human monoamine transporters, such as the dopamine and serotonin, couple ions with neurotransmitter uptake. Here the authors provide convincing data to show that K+ binding on the intraceullular side catalyses the return step of the transport cycle in LeuT by binding to one of the two sodium sites. The mechansitic consequences of K+ binding could either facilitate LeuT re-setting and/or prevent the rebinding and possible efflux of Na+ and substrate.

Reviewed by eLife