Reading List

Structural insights into binding-site access and ligand recognition by human ABCB1

1. Devanshu Kurre
2. Phuoc X Dang
3. Le T M Le
4. Varun V Gadkari
5. Amer Alam

Calculation of minimum energy pathways in transport proteins

1. Briony A Yorke
2. Helen M Ginn

Generating Multi-state Conformations of P-type ATPases with a Conditional Diffusion Model

1. Jingtian Xu
2. Yong Wang

Structure and function of the human apoptotic scramblase Xkr4

1. Sayan Chakraborty
2. Zhang Feng
3. Sangyun Lee
4. Omar E. Alvarenga
5. Aniruddha Panda
6. Shuming Zhang
7. Renato Bruni
8. George Khelashvili
9. Kallol Gupta
10. Alessio Accardi

Energy landscape of a Kv channel revealed by temperature steps while perturbing its electromechanical coupling

1. Bernardo I. Pinto-Anwandter
2. Carlos A. Z. Bassetto
3. Ramon Latorre
4. Francisco Bezanilla

Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease

1. Peter Rory Hall
2. Thibault Jouen-Tachoire
3. Marcus Schewe
4. Peter Proks
5. Thomas Baukrowitz
6. Elisabeth P. Carpenter
7. Simon Newstead
8. Karin E.J. Rödström
9. Stephen J. Tucker

Structure-based mechanism of RyR channel operation by calcium and magnesium ions

1. Alexandra Zahradníková
2. Jana Pavelková
3. Miroslav Sabo
4. Sefer Baday
5. Ivan Zahradník

Reviewed by Review Commons

Gz Enhanced Signal Transduction assaY (G _Z ESTY) for GPCR deorphanization

1. Luca Franchini
2. Joseph J. Porter
3. John D. Lueck
4. Cesare Orlandi

Human P2X4 receptor gating is modulated by a stable cytoplasmic cap and a unique allosteric pocket

1. Haoyuan Shi
2. Ismayn A. Ditter
3. Adam C. Oken
4. Steven E. Mansoor

Cryo-EM structures of ρ1 GABA _A receptors with antagonist and agonist drugs

1. Chen Fan
2. John Cowgill
3. Rebecca J. Howard
4. Erik Lindahl

Sensing endogenous RNA in living human cells using a CRISPR-activated protease

1. Katja Blumenstock
2. Alexander Hoch
3. Leo D. Hinterlang
4. Caroline I. Fandrey
5. Niels Schneberger
6. Gregor Hagelueken
7. Jonathan L. Schmid-Burgk

Deep learning–guided design of dynamic proteins

1. Amy B. Guo
2. Deniz Akpinaroglu
3. Christina A. Stephens
4. Michael Grabe
5. Colin A. Smith
6. Mark J. S. Kelly
7. Tanja Kortemme

Mechanistic insights from the atomic-level quaternary structure of short-lived GPCR oligomers of the human secretin receptor in live cells

1. Michael R. Stoneman
2. Thomas D. Killeen
3. Koki Yokoi
4. Gabriel Biener
5. Sanam Bista
6. Dhruba P. Adhikari
7. Sadia Rahman
8. Kaleeckal G. Harikumar
9. Laurence J. Miller
10. Ionel Popa
11. Valerică Raicu

Competitive modulation of K _V 1.2 gating by LMAN2 and Slc7a5

1. Damayantee Das
2. Shawn M. Lamothe
3. Anson A. Wong
4. Victoria A. Baronas
5. Harley T. Kurata

Activation of the Influenza B M2 Proton Channel (BM2)

1. Zhi Yue
2. Jiangbo Wu
3. Da Teng
4. Zhi Wang
5. Gregory A. Voth

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay

1. Leire Borrega-Roman
2. Bradley L. Hoare
3. Miroslav Kosar
4. Roman C. Sarott
5. Kacper J. Patej
6. Jara Bouma
7. Morgan Scott-Dennis
8. Eline J. Koers
9. Thais Gazzi
10. Leonard Mach
11. Sergio Barrondo
12. Joan Sallés
13. Wolfgang Guba
14. Eric Kusznir
15. Marc Nazaré
16. Arne C. Rufer
17. Uwe Grether
18. Laura H. Heitman
19. Erick M. Carreira
20. David A. Sykes
21. Dmitry B. Veprintsev

The N-terminal PAS domain directly regulates hERG channel gating in excised, inside-out patch-clamp fluorometry (PCF) recordings

1. Matthew C. Trudeau

Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785

1. Shan Zhang
2. Robyn Stix
3. Esam A Orabi
4. Nathan Bernhardt
5. José D Faraldo-Gómez

• Curated by eLife

  eLife Assessment

  This study represents an important advance in our understanding of how certain inhibitors affect the behavior of voltage gated potassium channels. Robust molecular dynamics simulation and analysis methods lead to a new proposed inhibition mechanism with convincing strength of support. This study has considerable significance for the fields of ion channel physiology and pharmacology and could aid in development of selective inhibitors for protein targets.

Reviewed by eLife

Single-molecule detection of transient dimerization of opioid receptors 2: Heterodimer blockage reduces morphine tolerance

1. Peng Zhou
2. Rinshi S. Kasai
3. Wakako Fujita
4. Taka A. Tsunoyama
5. Hiroshi Ueda
6. Simone Pigolotti
7. Takahiro K. Fujiwara
8. Akihiro Kusumi

Memorization Bias Impacts Modeling of Alternative Conformational States of Symmetric Solute Carrier Membrane Proteins with Methods from Deep Learning

1. G.V.T. Swapna
2. Namita Dube
3. Monica J. Roth
4. Gaetano T. Montelione