Review Commons

Latest preprint reviews

1. Specialization of ubiquitin ligases to distinct nucleic acid sensors

   This article has 8 authors:

   1. Ibrahim Syed
   2. Sheng Chen
   3. David J. Peeler
   4. Paul F. McKay
   5. Marco A. Briones-Orta
   6. Jennifer A. Bohn
   7. Robin J. Shattock
   8. Daniel Gonçalves-Carneiro

   Reviewed by Review Commons

2. The environmental stress response controls the biophysical properties of the cytoplasm and is critical for survival in quiescence

   This article has 11 authors:

   1. Lorena Kronig
   2. Carmen A. Weber
   3. Pablo Aurelio Gómez-García
   4. Jonas S. Fischer
   5. Christian Doerig
   6. Agnès Michel
   7. Paolo Ronchi
   8. Sarah Khawaja
   9. Paola Picotti
   10. Benoît Kornmann
   11. Karsten Weis

   Reviewed by Review Commons

3. Drosophila host defense mechanisms against filamentous fungal pathogens with diverse lifestyles

   This article has 6 authors:

   1. Guiqing Liu
   2. Yao Tian
   3. Mark Austin Hanson
   4. Prince Kumar Sah
   5. Jun Li
   6. Bruno Lemaitre

   Reviewed by Review Commons

4. A genotype-phenotype transformer to assess and explain polygenic risk

   This article has 7 authors:

   1. Ingoo Lee
   2. Zachary S. Wallace
   3. Yuqi Wang
   4. Sungjoon Park
   5. Hojung Nam
   6. Amit R. Majithia
   7. Trey Ideker

   Reviewed by Review Commons

5. Genetic and environmental determinants of multicellular-like phenotypes in fission yeast

   This article has 5 authors:

   1. Bence Kӧvér
   2. Céleste E. Cohen
   3. Markus Ralser
   4. Benjamin M. Heineike
   5. Jürg Bähler

   Reviewed by Review Commons

6. Plasmin activity and sterile inflammation synergize to promote lethal embryonic liver degeneration

   This article has 2 authors:

   1. Meng-Ling Wu
   2. Courtney T. Griffin

   Reviewed by Review Commons

7. Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of α-synuclein aggregation

   This article has 12 authors:

   1. Sandesh Neupane
   2. Lea Nikolić
   3. Lorenzo Maraio
   4. Thomas Goiran
   5. Nathan Karpilovsky
   6. Stefano Sellitto
   7. Vangelis Bouris
   8. Jiang-An Yin
   9. Ronald Melki
   10. Edward A. Fon
   11. Elena De Cecco
   12. Adriano Aguzzi

   Reviewed by Review Commons

8. Contractile peri-nuclear actomyosin network repositions peripheral and polar chromosomes to promote early kinetochore–microtubule interactions

   This article has 6 authors:

   1. Nooshin Sheidaei
   2. John K Eykelenboom
   3. Zuojun Yue
   4. Graeme Ball
   5. Alexander JR Booth
   6. Tomoyuki U Tanaka

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study demonstrates that a peri-nuclear actomyosin network, present in some types of human cells, facilitates kinetochore-spindle attachment of chromosomes in unfavorable locations - thereby suppressing their missegregation rate. This actomyosin network and its general role have been studied previously, but this study convincingly clarifies the underlying mechanism using a light-controlled perturbation and detailed tracking of kinetochore movement. The generality of the mechanism could be further supported by confirming the findings in non-synchronized cells and additional cell lines. The results may have implications for understanding chromosome missegregation in cancer cells.

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

9. Natural Killer Cell Receptor Signaling and Activation Depend on Cell Cycle Stages

   This article has 10 authors:

   1. Darren Wethington
   2. Indrani Nayak
   3. Helle Jensen
   4. William C. Stewart
   5. Oscar A. Aguilar
   6. Shih-Yu Chen
   7. Garry P. Nolan
   8. Gregory K. Behbehani
   9. Lewis L. Lanier
   10. Jayajit Das

   Reviewed by Review Commons

10. Lysosome-Dependent Sphingolipid Regulation as a potential therapeutic Target for Cohen Syndrome

    This article has 9 authors:

    1. Fabrizio Vacca
    2. Renuka Prasad
    3. Huda Barakullah
    4. Romain Da Costa
    5. Stefania Vossio
    6. Dimitri Moreau
    7. Woong Sun
    8. Howard Riezman
    9. Muhammad Ansar

    Reviewed by Review Commons