Review Commons

Latest preprint reviews

1. Direct visualization of emergent metastatic features within an ex vivo model of the tumor microenvironment

   This article has 6 authors:

   1. Libi Anandi
   2. Jeremy Garcia
   3. Manon Ros
   4. Libuše Janská
   5. Josephine Liu
   6. Carlos Carmona-Fontaine

   Reviewed by Review Commons

2. Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo

   This article has 8 authors:

   1. Sara Formichetti
   2. Agnieszka Sadowska
   3. Michela Ascolani
   4. Julia Hansen
   5. Kerstin Ganter
   6. Christophe Lancrin
   7. Neil Humphreys
   8. Mathieu Boulard

   Reviewed by Review Commons

3. Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response

   This article has 8 authors:

   1. Andrea Cottignies-Calamarte
   2. Flora Marteau
   3. Feifan He
   4. Sandrine Belouzard
   5. Jean Dubuisson
   6. Daniela Tudor
   7. Benoit Viollet
   8. Morgane Bomsel

   Reviewed by Review Commons

4. Evaluating the transcriptional regulators of arterial gene expression via a catalogue of characterized arterial enhancers

   This article has 5 authors:

   1. Svanhild Nornes
   2. Susann Bruche
   3. Niharika Adak
   4. Ian R McCracken
   5. Sarah De Val

   Reviewed by Review Commons

5. Distinct trafficking routes of polarized and non-polarized membrane cargoes in Aspergillus nidulans

   This article has 5 authors:

   1. Georgia Maria Sagia
   2. Xenia Georgiou
   3. Georgios Chamilos
   4. George Diallinas
   5. Sofia Dimou

   Reviewed by Review Commons

6. Mitochondrial Apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways

   This article has 12 authors:

   1. Melissa Lubeck
   2. Ritam Naha
   3. Yulia Schaumkessel
   4. Philipp Westhoff
   5. Anja Stefanski
   6. Patrick Petzsch
   7. Kai Stühler
   8. Karl Köhrer
   9. Andreas P. M. Weber
   10. Ruchika Anand
   11. Andreas S. Reichert
   12. Arun Kumar Kondadi

   Reviewed by Review Commons

7. Cytosolic and endoplasmic reticulum chaperones inhibit wt-p53 to increase cancer cells' survival by refluxing ER-proteins to the cytosol

   This article has 7 authors:

   1. Salam Dabsan
   2. Gali Zur
   3. Naim Abu-Freha
   4. Shahar Sofer
   5. Iris Grossman-Haham
   6. Ayelet Gilad
   7. Aeid Igbaria

   Reviewed by Review Commons

8. In vivo mapping of protein-protein interactions of schizophrenia risk factors generates an interconnected disease network

   This article has 3 authors:

   1. Daniel B. McClatchy
   2. Susan B. Powell
   3. John R. Yates

   Reviewed by Review Commons

9. DNA replication in primary hepatocytes without the six-subunit ORC

   This article has 12 authors:

   1. Róża K Przanowska
   2. Yuechuan Chen
   3. Takayuki-Okano Uchida
   4. Etsuko Shibata
   5. Xiaoxiao Hao
   6. Isaac Segura Rueda
   7. Kate Jensen
   8. Piotr Przanowski
   9. Anthony Trimboli
   10. Yoshiyuki Shibata
   11. Gustavo Leone
   12. Anindya Dutta

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable descriptive manuscript builds on prior research showing that the elimination of Origin Recognition Complex (ORC) subunits does not halt DNA replication. The authors obtain solid data using various methods to genetically remove one or two ORC subunits from specific tissues and still observe replication. The replication appears to be primarily endoreduplication, indicating that ORC-independent replication may promote genome reduplication without mitosis. The mechanism behind this ORC-independent replication remains to be elucidated. The study and mutants described herein lay the groundwork for future research to explore how cells compensate for the absence of ORC and to develop functional approaches to investigate this process. The reviewers suggested the observations could be supported by additional experiments. This work will be of interest to those studying genome duplication and replication.

   Reviewed by eLife, Review Commons

10. Capturing cell heterogeneity in representations of cell populations for image-based profiling using contrastive learning

    This article has 5 authors:

    1. Robert van Dijk
    2. John Arevalo
    3. Mehrtash Babadi
    4. Anne E. Carpenter
    5. Shantanu Singh

    Reviewed by Review Commons