Infectious Diseases (except HIV/AIDS)

Dengue viremia kinetics and effects on platelet count and clinical outcomes: An analysis of 2340 patients from Vietnam

1. Nguyen Lam Vuong
2. Nguyen Than Ha Quyen
3. Nguyen Thi Hanh Tien
4. Kien Duong Thi Hue
5. Huynh Thi Le Duyen
6. Phung Khanh Lam
7. Dong Thi Hoai Tam
8. Tran Van Ngoc
9. Thomas Jaenisch
10. Cameron P Simmons
11. Sophie Yacoub
12. Bridget A Wills
13. Ronald Geskus

• Curated by eLife

  eLife assessment

  This manuscript by Vuong and colleagues reports on the kinetics of viremia in a large set of individuals from Vietnam. In the large cohort, all 4 dengue serotypes are represented and the authors try to correlate viraemia measured at various days from illness onset with thrombocytopaenia and severe dengue, according to the WHO 2009 classification scheme. These are fundamental findings that provide compelling evidence of the importance of measuring viremia early in the phase of the disease. These data will help to inform the design of studies of antiviral drugs against dengue.

Reviewed by eLife

A randomized, double-blind phase 2b trial to evaluate efficacy of ChAd63-KH for treatment of post kala-azar dermal leishmaniasis

1. Brima M. Younis
2. Rebecca Wiggins
3. Eltahir A.G. Khalil
4. Mohamed Osman
5. Francesco Santoro
6. Chiara Sonnati
7. Ada Keding
8. Maria Novedrati
9. Giorgio Montesi
10. Ali Noureldein
11. Elmukashfi T.A. Elmukashfi
12. Ala Eldin Mustafa
13. Mohammed Alamin
14. Mohammed Saeed
15. Khalid Salman
16. Ahmed J. Suliman
17. Amin E.A. Musa
18. Alison M. Layton
19. Charles J.N. Lacey
20. Paul M. Kaye
21. Ahmed M. Musa

Reviewed by Rapid Reviews Infectious Diseases

Obesity Is Associated With Increased Pediatric Dengue Virus Infection and Disease: A 9-Year Cohort Study in Managua, Nicaragua

1. Reinaldo Mercado-Hernandez
2. Rachel Myers
3. Fausto Andres Bustos Carillo
4. José Victor Zambrana
5. Brenda López
6. Nery Sanchez
7. Aubree Gordon
8. Angel Balmaseda
9. Guillermina Kuan
10. Eva Harris

Reviewed by Rapid Reviews Infectious Diseases

Parallel Trends in an Unparalleled Pandemic Difference-in-differences for infectious disease policy evaluation

1. Shuo Feng
2. Alyssa Bilinski

Reviewed by Rapid Reviews Infectious Diseases

Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda

1. Moses R. Kamya
2. Joaniter I. Nankabirwa
3. Emmanuel Arinaitwe
4. John Rek
5. Maato Zedi
6. Catherine Maiteki-Sebuguzi
7. Jimmy Opigo
8. Sarah G. Staedke
9. Ambrose Oruni
10. Martin J. Donnelly
11. Bryan Greenhouse
12. Jessica Briggs
13. Paul J. Krezanoski
14. Teun Bousema
15. Philip J. Rosenthal
16. Peter Olwoch
17. Prasanna Jagannathan
18. Isabel Rodriguez-Barraquer
19. Grant Dorsey

Reviewed by Rapid Reviews Infectious Diseases

Proteomics analysis of peripheral blood monocytes from patients in early dengue infection reveals potential markers of subsequent fluid leakage

1. Nilanka Perera
2. Abhinav Kumar
3. Bevin Gangadharan
4. Diyanath Ranasinghe
5. Ananda Wijewickrama
6. Gathsaurie Neelika Malavige
7. Joanna L. Miller
8. Nicole Zitzmann

Reviewed by Rapid Reviews Infectious Diseases

Chronic pulmonary aspergillosis incidence in newly detected pulmonary tuberculosis cases during follow‐up

1. Dhouli Jha
2. Umesh Kumar
3. Ved Prakash Meena
4. Prayas Sethi
5. Amandeep Singh
6. Neeraj Nischal
7. Pankaj Jorwal
8. Surabhi Vyas
9. Gagandeep Singh
10. Immaculata Xess
11. Urvashi B. Singh
12. Sanjeev Sinha
13. Anant Mohan
14. Naveet Wig
15. Sushil Kumar Kabra
16. Animesh Ray

Reviewed by Rapid Reviews Infectious Diseases

Laboratory validation of a simplified DNA extraction protocol followed by a portable qPCR detection of M. tuberculosis DNA suitable for point of care settings

1. Tainá dos Santos Soares
2. Graziele Lima Bello
3. Ianca Moraes dos Santos Petry
4. Maria Rita Castilho Nicola
5. Larissa Vitoria da Silva
6. Regina Bones Barcellos
7. Joana Morez Silvestri
8. Maria Lucia Rossetti
9. Alexandre Dias Tavares Costa

Reviewed by Rapid Reviews Infectious Diseases

Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial

1. Joanna C Porter
2. Jamie Inshaw
3. Vincente Joel Solis
4. Emma Denneny
5. Rebecca Evans
6. Mia I Temkin
7. Nathalia De Vasconcelos
8. Iker Valle Aramburu
9. Dennis Hoving
10. Donna Basire
11. Tracey Crissell
12. Jesusa Guinto
13. Alison Webb
14. Hanif Esmail
15. Victoria Johnston
16. Anna Last
17. Thomas Rampling
18. Lena Lippert
19. Elisa Theresa Helbig
20. Florian Kurth
21. Bryan Williams
22. Aiden Flynn
23. Pauline T Lukey
24. Veronique Birault
25. Venizelos Papayannopoulos

• Curated by eLife

  eLife assessment

  This small-sized clinical trial comparing nebulized dornase-alfa to the best available care in patients hospitalized with COVID-19 pneumonia is valuable, but in its present form the paper is incomplete.

Reviewed by eLife, Rapid Reviews Infectious Diseases, ScreenIT

Strong isolation by distance and evidence of population microstructure reflect ongoing Plasmodium falciparum transmission in Zanzibar

1. Sean V Connelly
2. Nicholas F Brazeau
3. Mwinyi Msellem
4. Billy E Ngasala
5. Ozkan Aydemir
6. Varun Goel
7. Karamoko Niaré
8. David J Giesbrecht
9. Zachary R Popkin-Hall
10. Chris Hennelly
11. Zackary Park
12. Ann M Moormann
13. John M Ong'echa
14. Robert Verity
15. Safia Mohammed
16. Shija J Shija
17. Lwidiko E Mhamilawa
18. Ulrika Morris
19. Andreas Mårtensson
20. Jessica T Lin
21. Anders Björkman
22. Jonathan J Juliano
23. Jeffrey A Bailey

• Curated by eLife

  eLife assessment

  Connelly and colleagues provide convincing genetic evidence that importation from mainland Tanzania is a major source of Plasmodium falciparum lineages currently circulating in Zanzibar. This study also reveals ongoing local malaria transmission and occasional near-clonal outbreaks in Zanzibar. Overall, the manuscript effectively highlights the role of human movements in maintaining residual malaria transmission in an area targeted for intensive control interventions over the past decades and provides clear and valuable information for epidemiologists and public health professionals.

Reviewed by eLife