Immunology

The role of B cells in immune cell activation in polycystic ovary syndrome

1. Angelo Ascani
2. Sara Torstensson
3. Sanjiv Risal
4. Haojiang Lu
5. Gustaw Eriksson
6. Congru Li
7. Sabrina Teschl
8. Joana Menezes
9. Katalin Sandor
10. Claes Ohlsson
11. Camilla I Svensson
12. Mikael CI Karlsson
13. Martin Helmut Stradner
14. Barbara Obermayer-Pietsch
15. Elisabet Stener-Victorin

• Curated by eLife

  eLife assessment

  This manuscript provides important findings and would be of interest to specialists and researchers dealing with polycystic ovarian syndrome. Based on the compelling evidence, the authors present significant results on the role of B cells in immune cell activation in PCOS. However, there are some remarks regarding the statistics and data presentation.

Reviewed by eLife

New insights into the role of Cutibacterium acnes -derived extracellular vesicles in inflammatory skin disorders

1. Maria Pol Cros
2. Júlia Mir-Pedrol
3. Lorena Toloza
4. Nastassia Knödlseder
5. Marc Güell
6. Julien Maruotti
7. Christos C. Zouboulis
8. Maria-José Fábrega Fernández

Reviewed by Review Commons

TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity

1. William D Jackson
2. Chiara Giacomassi
3. Sophie Ward
4. Amber Owen
5. Tiago C Luis
6. Sarah Spear
7. Kevin J Woollard
8. Cecilia Johansson
9. Jessica Strid
10. Marina Botto

• Curated by eLife

  eLife assessment

  This important work advances our understanding of TLR7 signaling at epithelial surfaces that drives monocytes expansion and its impact on viral responses. The evidence supporting this conclusion is solid, particularly data demonstrating TLR7 stimulation and the requirement for TLR7 in the monocyte expansion. The work will be of interest to immunologists and virologists.

Reviewed by eLife

Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers

1. Carlos Castrillon
2. Lea Simoni
3. Theo van den Broek
4. Cees van der Poel
5. Elliot H Akama-Garren
6. Minghe Ma
7. Michael C Carroll

• Curated by eLife

  eLife assessment

  Understanding the heterogeneity of the B cell response induced in autoimmune individuals is important for the development of therapies designed to target the cells underlying disease progression. Here the authors use a new mouse model of autoimmunity to assess the heterogeneity of the B cell response using single-cell RNA-sequencing and BCR-sequencing and found that these B cell responses are similar to those by exogenous protein immunization.

Reviewed by eLife

Dual function of Zika virus NS2B-NS3 protease

1. Sergey A. Shiryaev
2. Piotr Cieplak
3. Anton Cheltsov
4. Robert C. Liddington
5. Alexey V. Terskikh

Reviewed by Review Commons

Candida albicans promotes neutrophil extracellular trap formation and leukotoxic hypercitrullination via the peptide toxin candidalysin

1. Lucas Unger
2. Emelie Backman
3. Borko Amulic
4. Fernando M. Ponce-Garcia
5. Sujan Yellagunda
6. Renate Krüger
7. Horst von Bernuth
8. Johan Bylund
9. Bernhard Hube
10. Julian R. Naglik
11. Constantin F. Urban

Reviewed by Review Commons

Maternal group 2 innate lymphoid cells contribute to fetal growth and protection from endotoxin-induced abortion in mice

1. Elisa Balmas
2. Batika MJ Rana
3. Russell S Hamilton
4. Norman Shreeve
5. Jens Kieckbusch
6. Irving Aye
7. Delia A Hawkes
8. Sophie Trotter
9. Jorge López-Tello
10. Hannah EJ Yong
11. Salvatore Valenti
12. Amanda N Sferruzi-Perri
13. Francesca Gaccioli
14. Andrew NJ McKenzie
15. Francesco Colucci

• Curated by eLife

  eLife assessment

  This important study describes the protective role of group 2 innate lymphoid cells (ILC2s) in tissue physiology and contributes to immunity, inflammatory pathology, and metabolism in maintaining homeostasis during pregnancy. The authors provide convincing evidence that ILC2s have new roles distinct from parasite protection and allergy inducers. Uterine ILC2s are key immune cells during normal and complicated pregnancies.

Reviewed by eLife

CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance

1. Yu Li
2. Pablo Guaman Tipan
3. Hilary J Selden
4. Jayashree Srinivasan
5. Laura P Hale
6. Lauren IR Ehrlich

• Curated by eLife

  eLife assessment

  This paper will be of broad interest to immunologists that study T cell responses and formation of the peripheral T cell compartment. Using elegant live imaging approaches, the authors provide convincing evidence in support of a revised model for how positive-selected thymocytes are called to the thymus medulla to interact with distinct antigen-presenting cells. The work makes an important contribution to the field by identifying previously unappreciated complexities related to cellular movement during T cell generation.

Reviewed by eLife

Multilevel human secondary lymphoid immune system compartmentalization revealed by complementary multiplexing and mass spectrometry imaging approaches

1. Benjamin L. Oyler
2. Jeferson A. Valencia-Dávila
3. Eirini Moysi
4. Adam Molyvdas
5. Kalliopi Ioannidou
6. Kylie March
7. David Ambrozak
8. Laurence de Leval
9. Giulia Fabozzi
10. Amina S. Woods
11. Richard A. Koup
12. Constantinos Petrovas

Reviewed by Arcadia Science

Kaempferol Suppresses the Activation of Mast Cells by Modulating the Expression of FcεRI and SHIP1

1. Kazuki Nagata
2. Sanae Araumi
3. Daisuke Ando
4. Naoto Ito
5. Miki Ando
6. Yuki Ikeda
7. Miki Takahashi
8. Sakura Noguchi
9. Yayoi Yasuda
10. Nobuhiro Nakano
11. Tomoaki Ando
12. Mutsuko Hara
13. Takuya Yashiro
14. Masakazu Hachisu
15. Chiharu Nishiyama

Reviewed by Arcadia Science