Immunology

Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies

1. Leo Hanke
2. Daniel J. Sheward
3. Alec Pankow
4. Laura Perez Vidakovics
5. Vivien Karl
6. Changil Kim
7. Egon Urgard
8. Natalie L. Smith
9. Juan Astorga-Wells
10. Simon Ekström
11. Jonathan M. Coquet
12. Gerald M. McInerney
13. Ben Murrell

Reviewed by ScreenIT

Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine

1. Kevin J. Kramer
2. Erin M. Wilfong
3. Kelsey Voss
4. Sierra M. Barone
5. Andrea R. Shiakolas
6. Nagarajan Raju
7. Caroline E. Roe
8. Naveenchandra Suryadevara
9. Lauren M. Walker
10. Steven C. Wall
11. Ariana Paulo
12. Samuel Schaefer
13. Debolanle Dahunsi
14. Camille S. Westlake
15. James E. Crowe
16. Robert H. Carnahan
17. Jeffrey C. Rathmell
18. Rachel H. Bonami
19. Ivelin S. Georgiev
20. Jonathan M. Irish

Reviewed by ScreenIT

Probiotic consortia improve anti-viral immunity to SARS-CoV-2 in Ferrets

1. J Lehtinen Markus
2. Kumar Ritesh
3. Zabel Bryan
4. M Mäkelä Sanna
5. Nedveck Derek
6. Tang Peipei
7. Latvala Sinikka
8. Guery Sebastien
9. R Budinoff Charles

Reviewed by ScreenIT

Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors

1. Daichao Wu
2. Alexander Kolesnikov
3. Rui Yin
4. Johnathan D. Guest
5. Ragul Gowthaman
6. Anton Shmelev
7. Yana Serdyuk
8. Dmitry V. Dianov
9. Grigory A. Efimov
10. Brian G. Pierce
11. Roy A. Mariuzza

Reviewed by ScreenIT

Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects macaques from infection

1. Guidenn Sulbaran
2. Pauline Maisonnasse
3. Axelle Amen
4. Gregory Effantin
5. Delphine Guilligay
6. Nathalie Dereuddre-Bosquet
7. Judith A. Burger
8. Meliawati Poniman
9. Marloes Grobben
10. Marlyse Buisson
11. Sebastian Dergan Dylon
12. Thibaut Naninck
13. Julien Lemaître
14. Wesley Gros
15. Anne-Sophie Gallouët
16. Romain Marlin
17. Camille Bouillier
18. Vanessa Contreras
19. Francis Relouzat
20. Daphna Fenel
21. Michel Thepaut
22. Isabelle Bally
23. Nicole Thielens
24. Franck Fieschi
25. Guy Schoehn
26. Sylvie van der Werf
27. Marit J. van Gils
28. Rogier W. Sanders
29. Pascal Poignard
30. Roger Le Grand
31. Winfried Weissenhorn

Reviewed by ScreenIT

Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination

1. Alice Cho
2. Frauke Muecksch
3. Dennis Schaefer-Babajew
4. Zijun Wang
5. Shlomo Finkin
6. Christian Gaebler
7. Victor Ramos
8. Melissa Cipolla
9. Pilar Mendoza
10. Marianna Agudelo
11. Eva Bednarski
12. Justin DaSilva
13. Irina Shimeliovich
14. Juan Dizon
15. Mridushi Daga
16. Katrina G. Millard
17. Martina Turroja
18. Fabian Schmidt
19. Fengwen Zhang
20. Tarek Ben Tanfous
21. Mila Jankovic
22. Thiago Y. Oliveria
23. Anna Gazumyan
24. Marina Caskey
25. Paul D. Bieniasz
26. Theodora Hatziioannou
27. Michel C. Nussenzweig

Reviewed by ScreenIT

Severe COVID-19 Shares a Common Neutrophil Activation Signature with Other Acute Inflammatory States

1. Lena F. Schimke
2. Alexandre H. C. Marques
3. Gabriela Crispim Baiocchi
4. Caroline Aliane de Souza Prado
5. Dennyson Leandro M. Fonseca
6. Paula Paccielli Freire
7. Desirée Rodrigues Plaça
8. Igor Salerno Filgueiras
9. Ranieri Coelho Salgado
10. Gabriel Jansen-Marques
11. Antonio Edson Rocha Oliveira
12. Jean Pierre Schatzmann Peron
13. Gustavo Cabral-Miranda
14. José Alexandre Marzagão Barbuto
15. Niels Olsen Saraiva Camara
16. Vera Lúcia Garcia Calich
17. Hans D. Ochs
18. Antonio Condino-Neto
19. Katherine A. Overmyer
20. Joshua J. Coon
21. Joseph Balnis
22. Ariel Jaitovich
23. Jonas Schulte-Schrepping
24. Thomas Ulas
25. Joachim L. Schultze
26. Helder I. Nakaya
27. Igor Jurisica
28. Otávio Cabral-Marques

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Langerhans cells and cDC1s play redundant roles in mRNA-LNP induced protective anti-influenza and anti-SARS-CoV-2 immune responses

1. Sonia Ndeupen
2. Aurélie Bouteau
3. Christopher Herbst
4. Zhen Qin
5. Sonya Jacobsen
6. Nicholas E. Powers
7. Zachary Hutchins
8. Drishya Kurup
9. Leila Zabihi Diba
10. Megan Watson
11. Holly Ramage
12. Botond Z. Igyártó

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A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice

1. Benkun Zou
2. Michael Goodwin
3. Danial Saleem
4. Wei Jiang
5. Jianguo Tang
6. Yiwei Chu
7. Robert S Munford
8. Mingfang Lu

• Curated by eLife

  Evaluation Summary:

  The paper describes novel structures of a protein recently reported to function as a mechanosensitive ion channel. Surprisingly, the structures and functional data rather support the formerly suggested role of this protein in lipid metabolism. The paper is of relevance for ion channel field and for those interested in fatty acid metabolism.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

SARS-CoV-2 Exploits Sexually Dimorphic and Adaptive IFN and TNFa Signaling to Gain Entry into Alveolar Epithelium

1. Yan Wang
2. Sreeharsha Gurrapu
3. Hong Chen
4. Sara Laudato
5. Emily Caggiano
6. Yan Jiang
7. Hsiang-Hsi Ling
8. Filippo G. Giancotti

Reviewed by ScreenIT