Transition of Antibody Titers after SARS-CoV-2 mRNA Vaccination in Japanese Healthcare Workers

  1. Masahiro Kitabatake
  2. Noriko Ouji-Sageshima
  3. Shota Sonobe
  4. Ryutaro Furukawa
  5. Makiko Konda
  6. Atsushi Hara
  7. Hiroyasu Aoki
  8. Yuki Suzuki
  9. Natsuko Imakita
  10. Akiyo Nakano
  11. Yukio Fujita
  12. Shigeyuki Shichino
  13. Ryuichi Nakano
  14. Satoshi Ueha
  15. Kei Kasahara
  16. Shigeo Muro
  17. Hisakazu Yano
  18. Kouji Matsushima
  19. Toshihiro Ito

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Abstract

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  1. Version published to 10.7883/yoken.jjid.2022.041
  2. ScreenIT

    SciScore for 10.1101/2021.12.28.21268435: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsConsent: All study participants provided written informed consent.
    IRB: The Nara Medical University Ethics Committee approved the study (No. 3168).
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    This study had some limitations, including a small sample size, no use of mutant strains in the neutralization responses, and an absence of cellular immune responses. Additionally, other than for the humoral response, data are lacking regarding cell-mediated immune responses and to what extent this protection contributes to the long-term efficacy of the vaccine. Therefore, the effects of long-term transition and boosters on cell-mediated immunity should be investigated in detail.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.12.28.21268435v1 on medRxiv