Breakthrough Infection With Severe Acute Respiratory Syndrome Coronavirus 2 Among Healthcare Workers in Delhi: A Single-Institution Study
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SciScore for 10.1101/2021.06.07.21258447: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IACUC: Ethics The study was approved by the Institutional Ethics Committee (F.1/IEC/MAMC/(84/02/2021/No338).
Consent: Verbal consent was obtained from the HCWs who responded to the telephonic interviews prior to the initiation of the survey.Sex as a biological variable The mean (SD) age of the participants was 29.1 (9.9) years including 212 (65%) males and 114 (35%) females. Randomization not detected. Blinding not detected. Power Analysis The sample size was calculated considering the prevalence of breakthrough infection among HCWs in India as 13.3% as reported in a study from a chronic care facility in Delhi [12], at 95% confidence level, 4% precision, and 10% non-response. Table 2: Resources
… SciScore for 10.1101/2021.06.07.21258447: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IACUC: Ethics The study was approved by the Institutional Ethics Committee (F.1/IEC/MAMC/(84/02/2021/No338).
Consent: Verbal consent was obtained from the HCWs who responded to the telephonic interviews prior to the initiation of the survey.Sex as a biological variable The mean (SD) age of the participants was 29.1 (9.9) years including 212 (65%) males and 114 (35%) females. Randomization not detected. Blinding not detected. Power Analysis The sample size was calculated considering the prevalence of breakthrough infection among HCWs in India as 13.3% as reported in a study from a chronic care facility in Delhi [12], at 95% confidence level, 4% precision, and 10% non-response. Table 2: Resources
Software and Algorithms Sentences Resources Statistical analysis Data was entered in Epidata 3.1 (single entered) and analysed with IBM SPSS Version 25 (Armonk, NY). SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:However, there are certain study limitations. First, since infection status of the HCWs was based on self-report in the absence of a mandatory testing policy, mostly symptomatic breakthrough infections diagnosed with RT-PCR or the Ag test were likely to be captured while asymptomatic infections also capable of viral transmission were potentially omitted. Second, although, we observed high rates of transmission in the household members of the HCWs, the vaccination status in the infected household members was not recorded. Third, non-breakthrough infection rate could be inflated since the HCWs at the time of administration of their first dose of vaccine may already have been infected. Fourth, comorbidity status was not ascertained in the participants although the likelihood of underlying morbidities in the HCWs was less considering their low median age. Consequently, future studies should assess the extent of vaccine induced antibody response and protection after vaccination with Covid-19 vaccines in patients with diabetes, heart disease, chronic kidney disease, and older people at risk of reduced protection in addition to pre-existing concerns causally linked with the occurrence of severe disease. A final limitation is that the sample size was not adequately powered to detect statistically significant differences between subgroups. In conclusion, breakthrough infections represent a major public health challenge in ending the Covid-19 pandemic. Robust surveillance through large...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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