Comparison of Rapid Antigen Tests' Performance Between Delta and Omicron Variants of SARS-CoV-2
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SciScore for 10.1101/2022.02.27.22271090: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Participants provided electronic consent to participate in the study through the app, and individuals under 18 years were required to assent and provide written parental consent.
IRB: The study protocol for the main study was approved by the Institutional Review Board at UMass Chan Medical School and externally by Western Institutional Review Board.
Field Sample Permit: This assay is a real-time RT-PCR assay based on the Roche cobas SARS-CoV-2 assay and EUA-authorized for use with specimens collected with the Quest Diagnostics Collection Kit for COVID-19.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: …
SciScore for 10.1101/2022.02.27.22271090: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Participants provided electronic consent to participate in the study through the app, and individuals under 18 years were required to assent and provide written parental consent.
IRB: The study protocol for the main study was approved by the Institutional Review Board at UMass Chan Medical School and externally by Western Institutional Review Board.
Field Sample Permit: This assay is a real-time RT-PCR assay based on the Roche cobas SARS-CoV-2 assay and EUA-authorized for use with specimens collected with the Quest Diagnostics Collection Kit for COVID-19.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources All RT-PCR tests were performed at a single CLIA-certified laboratory (Quest Labs, Marlborough, MA) using the Quest Diagnostics RC SARS-CoV-2 assay. Questsuggested: (QUEST, RRID:SCR_005210)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:However, these limitations are non-differential and unlikely to bias the comparison of Ag-RDT performance between Delta and Omicron variants. Furthermore, the data collected from this study illustrates performance of Ag-RDT self-collected at home, which is a different setting than proctored or on-site administration of Ag-RDT with guidance from trained individuals or when tests are performed by health care professionals. Early epidemiologic studies have shown decreased and delayed sensitivity of Ag-RDT in detecting the Omicron variant in comparison to saliva RT-PCR testing. Notably, in a pre-print, Adamson et al. reported that among 28 people with a positive saliva RT-PCR test with suspected Omicron variant infection and CT value < 29, none tested positive on nasal Ag-RDT within 24 hours.10 Additionally, they reported a median lag of 3 days from saliva RT-PCR positivity to a positive Ag-RDT from nasal swab. By contrast, among the infections where initial nasal RT-PCR+ CT value was lower than 30, our study found that Ag-RDT was positive within 48 hours in 33 out of the 34 instances. In the sole case where Ag-RDT+ was not recorded within 24 hours of the initial RT-PCR+ with a CT value < 30, a subsequent Ag-RDT was not performed. We also found a sensitivity of 87.2% with Ag-RDT performed on same-day as RT-PCR+ with CT count < 30 among individuals infected with the Omicron variant, which is similar to a separate report that evaluated similar performance among predominantly sympto...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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