Quantification of Occupational and Community Risk Factors for SARS-CoV-2 Seropositivity Among Health Care Workers in a Large U.S. Health Care System

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Abstract

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  1. SciScore for 10.1101/2020.10.30.20222877: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    NIH rigor criteria are not applicable to paper type.

    Table 2: Resources

    Antibodies
    SentencesResources
    The serologic test used to analyze participant samples was developed at the Emory Medical Laboratory and measures IgG antibody to the receptor binding domain of the SARS-CoV-2 spike protein.
    SARS-CoV-2 spike protein.
    suggested: None
    Software and Algorithms
    SentencesResources
    We analyzed data from Emory Healthcare, which includes 11 hospitals, 250 provider locations, and approximately 25,000 employees and medical staff members based in the Atlanta, Georgia, metropolitan area.
    Emory Healthcare
    suggested: (One Mind Biospecimen Bank Listing, RRID:SCR_004193)

    Results from OddPub: Thank you for sharing your code.


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    There are several limitations to this analysis. First, serological testing was voluntary, which may introduce bias if groups more likely to participate were also more (or less) likely to be seropositive. We partially adjusted for participation using demographic characteristics of HCWs overall. This adjustment at least partially accounts for poor representation of Black HCWs, in whom seroprevalence was higher than the population average, among those who volunteered for testing. However, other factors related to infection risk may have influenced participation. Second, a test with imperfect specificity in a population where seroprevalence is low will likely result in some false positives which may bias aORs towards the null. Third, we could not account for rapidly evolving infection prevention practices early in the pandemic and social behavior inside or outside the workplace. Lastly, the large influx of COVID-19 patients caused major shifts in care delivery and personnel deployment. Many HCWs worked in multiple locations and even different roles. In conclusion, using a model incorporating demographic, community, and occupational risk factors for infection, we quantified community and occupational risk of SARS-CoV-2 seropositivity in HCWs. We found that most of this risk is due to community exposure; ongoing efforts to keep the healthcare workforce safe should emphasize risk mitigation in and outside the workplace. After adjusting for a number of community and occupational risk...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

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