Short-read whole-genome sequencing identifies the Tg(Tal1-cre/ERT)42-056Jrg transgene insertion site on mouse chromosome 4

  1. Xiaodi Wu
  2. Maya C. Bagish
  3. Pablo Sánchez Vela
  4. Alexander G. Goglia
  5. Ross L. Levine
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Abstract

Tg(Tal1-cre/ERT)42-056Jrg, also known as HSC-Scl-CreERT, is a well-used transgenic allele that enables genetic manipulation in mouse hematopoietic cells. Using short-read whole-genome sequencing, we identified the transgene insertion site on chromosome 4 approximately 6 kb upstream of Echdc2.

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  1. Mentioned by @biorxiv-genetic.bsky.social on Bluesky

    Short-read whole-genome sequencing identifies the Tg(Tal1-cre/ERT)42-056Jrg transgene insertion site on mouse chromosome 4 https://www.biorxiv.org/content/10.64898/2026.11.04.764251v1

  2. Mentioned by @biorxivpreprint.bsky.social on Bluesky

    Short-read whole-genome sequencing identifies the Tg(Tal1-cre/ERT)42-056Jrg transgene insertion site on mouse chromosome 4 https://www.biorxiv.org/content/10.64898/2026.11.04.764251v1

  3. Version published to 10.64898/2026.11.04.764251v1 on bioRxiv