Oligodendrocyte precursor cell death does not contribute to lifelong population homeostasis
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Oligodendrocyte precursor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes throughout life, but it is unclear if their continuous self-renewal is balanced by cell death. We find that OPCs do not die during development or adulthood, nor during remyelination, acute systemic inflammation, or aging. These findings challenge the assumption that spontaneous OPC death is common and reveal that OPC homeostasis does not depend on programmed cell death.
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I always assumed that oligodendrocyte precursor cells regularly die to balance ongoing proliferation and oligodendrocyte generation. Postdoc Yasmine Kamen finally formally tested this. Yasmine found that OPCs almost never die, even during development and aging. www.biorxiv.org/content/10.6...
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Oligodendrocyte precursor cell death does not contribute to lifelong population homeostasis https://www.biorxiv.org/content/10.64898/2026.10.28.762467v1
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Oligodendrocyte precursor cell death does not contribute to lifelong population homeostasis https://www.biorxiv.org/content/10.64898/2026.10.28.762467v1
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