Memory Intraindividual Variability and its Association with Hippocampal Integrity in Older Latino Adults Without Dementia
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Introduction
Cognitive intraindividual variability (IIV), a measure of fluctuation in performance across time or tasks, is an emerging marker of cognitive decline. However, little is known about within-domain IIV in Latino adults. To address this gap, we examined memory IIV and hippocampal integrity in older Latino individuals.
Methods
Sixty-seven participants from the Boston Latino Aging Study underwent cognitive testing and MRI. Linear regressions assessed whether memory IIV was associated with hippocampal volume and hippocampus-cingulum tract fractional anisotropy. Additional analyses evaluated associations using mean memory performance as the outcome.
Results
Higher mean performance was associated with greater hippocampal volume ( β =0.24, p =.03), while memory IIV was not ( β =0.028, p =.84). Higher memory IIV was associated with lower fractional anisotropy in the hippocampus-cingulum tract ( β =-0.34, p <.01), while mean performance was not ( β =-0.07, p =.52).
Discussion
Memory IIV may be more closely linked to hippocampal white matter, while mean memory performance may better reflect hippocampal volume.
