Oxazolidinone antibiotics exhibit potent in vitro activity against Gram-positive bacterial endophthalmitis isolates
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Purpose
Vancomycin-resistant Gram-positive organisms represent a potential therapeutic challenge in endophthalmitis. To evaluate alternative treatment options, the FDA-approved oxazolidinones linezolid (LZD) and tedizolid (TZD) were tested against a collection of Gram-positive bacterial endophthalmitis isolates.
Methods
Minimum inhibitory concentrations (MICs) were determined using epsilometers (Etest strips) for coagulase negative staphylococci (CoNS, n=20), Staphylococcus aureus (n=18), Bacillus species (n=10), Enterococcus species (n=5), and Streptococcus pneumoniae (n=1). Available CLSI and EUCAST breakpoints were applied to determine susceptibility.
Results
TZD exhibited a >5-fold reduction in median MIC compared with LZD across all organisms tested (p<0.0001). MIC 90 values for CoNS were 2.0 µg/ml for LZD and 0.25 µg/ml for TZD. For S. aureus , MIC 90 values were 1.5 µg/ml (LZD) and 0.19 µg/ml (TZD). For Bacillus spp., MIC 90 values were 1.0 µg/ml (LZD) and 0.25 µg/ml (TZD). Among Enterococcus species, the MIC range was 0.5-4.0 µg/ml (LZD) and 0.064-0.75 µg/ml (TDZ). The single S. pneumoniae strain had a MIC of 0.5 for LZD and 0.064 for TZD. All isolates were susceptible to TZD. One Enterococcus isolate was non-susceptible to LZD; the remaining isolates were susceptible.
Conclusions
LZD and TZD demonstrated in vitro activity against Gram-positive bacterial endophthalmitis isolates, with TZD displaying consistently lower MICs than LZD. These findings suggest that oxazolidinones may represent potential alternatives when vancomycin cannot be used, including infections caused by vancomycin-resistant Gram-positive organisms. Given their excellent oral bioavailability, favorable safety profile, and reported anti-virulence effects in certain pathogens, further evaluation of oxazolidinones for the treatment of intraocular infections is warranted.
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Authors published a paper in Biorxiv, they used GraphPad Prism in the study. Including #RRIDs will make this less ambiguous. SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #RRID #STMpublishing
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Oxazolidinone antibiotics exhibit potent in vitro activity against Gram-positive bacterial endophthalmitis isolates https://www.biorxiv.org/content/10.64898/2026.10.05.756736v1
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Oxazolidinone antibiotics exhibit potent in vitro activity against Gram-positive bacterial endophthalmitis isolates https://www.biorxiv.org/content/10.64898/2026.10.05.756736v1
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