Transcriptome profiling of cell-free RNAs in prostate cancer patients on active surveillance
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In this feasibility study, plasma cfRNA transcriptomes from 64 men with prostate cancer on active surveillance revealed differences between stable disease and progression to radical prostatectomy and suggested a predominantly non-tumour origin of circulating RNA. These findings demonstrate the feasibility of cfRNA transcriptomic analysis in this setting and support its further investigation as a minimally invasive adjunct for personalised risk stratification and monitoring.
